Results 51 to 60 of about 2,154,717 (261)

Research progress of ultrasonic in-situ nondestructive testing technology for aircraft structure

Journal of Aeronautical Materials
Damage detection is a critical link of aviation equipment development，field operation and maintenance，which directly affects the development process and service safety of aircraft structure.
ZHANG Wei, FAN Junling, ZHAN Shaozheng, YANG Pengfei, JIA Wenbo   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Random Vibration Fatigue Life Analysis of Aeroengine Bolts Using the Frequency-Domain Method

Fatigue of Aircraft Structures
Bolt connections are widely used in aircraft engines due to their advantages of high stiffness, low weight, and ease of assembly and disassembly. However, they are subjected to complex stress states in service, including high preloads, combustion-induced
Tian Lilin, Wang Jun, Zhang Chaofeng, Guo Yuchao, Chang Liang   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Optimum Selection Analysis of Composite Cap Cone

Engineering Proceedings
An in-depth analysis was conducted on the dynamic strength design optimization of carbon fiber composite cap cones in aircraft engines subjected to bird body impacts. Initially, the top, 1/4, 1/2, 3/4, and root positions of the cap cone’s generatrix were
Jijun Liu, Yongping Jiang, Kaixiang Li, Yafeng Wang   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Mechanism-Driven Forward Design Methodology and Experimental Validation of Dry Friction Dampers for Turbine Blade Vibration Control

Machines
To elucidate the damping mechanism of platform dry friction dampers for turbine blades and optimize their design parameters, this study establishes a two-dimensional global–local unified sliding dry friction damping model.
Qinqin Mu, Qun Yan, Chao Hang, Yonghui Chen   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source