Results 61 to 70 of about 2,154,717 (261)

Calculation and analysis of heat generation of aero-engine bearing-support system

Hangkong gongcheng jinzhan
The heat source analysis and quantitative calculation of heat production of the bearing-support structure system can provide a reliable basis for the thermal protection design of the bearing cavity.
SUN Peng, MU Qinqin, CHEN Yonghui, YAN Qun   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A review of experimental modal analysis methods and their applications in aerospace vehicles

Hangkong gongcheng jinzhan
Experimental modal analysis is a method of measuring the natural vibration characteristics of a structure through experiments. The analysis results are mainly used to modify the structural dynamic models and provide data support for structural dynamics ...
HUI Xinyu, LIU Fan, LI Xiaodong, SONG Qiaozhi   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Study on high-low cycle fretting fatigue life of Inconel718 tenon structure

Hangkong gongcheng jinzhan
The turbine blades of aero-engines are subjected to cyclic high-low cycle loads in actual service environments，which is a typical high-low cycle micro motion fatigue condition. The frequent occurrence of fatigue fracture in turbine blades due to fretting
YANG Xiaolin, MU Qinqin, CHEN Yonghui, YAN Qun   +3 more
doaj   +1 more source

Acoustic emission characterization of sliding wear under condition of direct and inverse transformations in low-temperature degradation aged Y-TZP and Y-TZP-AL2O3

Friction, 2018
In this research, results of the investigation of the sliding friction and wear of yttria-stabilized tetragonal zirconia polycrystalline (Y-TZP) and Y-TZP-Al2O3 samples preliminarily subjected to low-temperature degradation are reported.
Nikolai L. Savchenko, Andrey V. Filippov, Sergei Yu Tarasov, Andrey I. Dmitriev, Evgeny V. Shilko, Aleksandr S. Grigoriev   +5 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Ground Strength Test Technique of Variable-Camber Wing Leading Edge

Biomimetics
Morphing wing technology is crucial for enhancing the flight performance of aircraft. To address the monitoring challenges of full-scale variable-camber leading edges under flight conditions, this study introduces a ground-based strength testing ...
Shanshan Li, Xianmin Chen, Zhigang Wang, Yuanbo Liang   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Post-Buckling Failure Mechanism and Optimal Tapered Termination Design for Composite Hat-Stiffened Panels

Aerospace
Composite hat-stiffened panels are widely used in civil aircraft structural design as typical closed-section stiffened components with high load-carrying efficiency.
Guofan Zhang, Chunhua Wan, Liang Chang, Xiaohua Nie   +3 more
doaj   +1 more source