Results 81 to 90 of about 7,757,408 (296)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Optimum Selection Analysis of Composite Cap Cone

Engineering Proceedings
An in-depth analysis was conducted on the dynamic strength design optimization of carbon fiber composite cap cones in aircraft engines subjected to bird body impacts. Initially, the top, 1/4, 1/2, 3/4, and root positions of the cap cone’s generatrix were
Jijun Liu, Yongping Jiang, Kaixiang Li, Yafeng Wang   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Calculation and analysis of heat generation of aero-engine bearing-support system

Hangkong gongcheng jinzhan
The heat source analysis and quantitative calculation of heat production of the bearing-support structure system can provide a reliable basis for the thermal protection design of the bearing cavity.
SUN Peng, MU Qinqin, CHEN Yonghui, YAN Qun   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A review of experimental modal analysis methods and their applications in aerospace vehicles

Hangkong gongcheng jinzhan
Experimental modal analysis is a method of measuring the natural vibration characteristics of a structure through experiments. The analysis results are mainly used to modify the structural dynamic models and provide data support for structural dynamics ...
HUI Xinyu, LIU Fan, LI Xiaodong, SONG Qiaozhi   +3 more
doaj   +1 more source

Acoustic emission characterization of sliding wear under condition of direct and inverse transformations in low-temperature degradation aged Y-TZP and Y-TZP-AL2O3

Friction, 2018
In this research, results of the investigation of the sliding friction and wear of yttria-stabilized tetragonal zirconia polycrystalline (Y-TZP) and Y-TZP-Al2O3 samples preliminarily subjected to low-temperature degradation are reported.
Nikolai L. Savchenko, Andrey V. Filippov, Sergei Yu Tarasov, Andrey I. Dmitriev, Evgeny V. Shilko, Aleksandr S. Grigoriev   +5 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Study on high-low cycle fretting fatigue life of Inconel718 tenon structure

Hangkong gongcheng jinzhan
The turbine blades of aero-engines are subjected to cyclic high-low cycle loads in actual service environments，which is a typical high-low cycle micro motion fatigue condition. The frequent occurrence of fatigue fracture in turbine blades due to fretting
YANG Xiaolin, MU Qinqin, CHEN Yonghui, YAN Qun   +3 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source