Results 91 to 100 of about 3,939,893 (294)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Optimum Selection Analysis of Composite Cap Cone

Engineering Proceedings
An in-depth analysis was conducted on the dynamic strength design optimization of carbon fiber composite cap cones in aircraft engines subjected to bird body impacts. Initially, the top, 1/4, 1/2, 3/4, and root positions of the cap cone’s generatrix were
Jijun Liu, Yongping Jiang, Kaixiang Li, Yafeng Wang   +3 more
doaj   +1 more source

~>PDF @*BOOK Strength of Materials: Mechanics of Solids *Full Online

, 2020
Read Or Download Strength of Materials: Mechanics of Solids Full Books By R.K. Rajput Read Online => Read Strength of Materials: Mechanics of Solids Download Book => Download Strength of Materials: Mechanics of Solids Strength of Materials: Mechanics ...
~>PDF @*BOOK Strength of Materials: Mechanics of Solids *Full Online
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Mechanism-Driven Forward Design Methodology and Experimental Validation of Dry Friction Dampers for Turbine Blade Vibration Control

Machines
To elucidate the damping mechanism of platform dry friction dampers for turbine blades and optimize their design parameters, this study establishes a two-dimensional global–local unified sliding dry friction damping model.
Qinqin Mu, Qun Yan, Chao Hang, Yonghui Chen   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Calculation and analysis of heat generation of aero-engine bearing-support system

Hangkong gongcheng jinzhan
The heat source analysis and quantitative calculation of heat production of the bearing-support structure system can provide a reliable basis for the thermal protection design of the bearing cavity.
SUN Peng, MU Qinqin, CHEN Yonghui, YAN Qun   +3 more
doaj   +1 more source

Acoustic emission characterization of sliding wear under condition of direct and inverse transformations in low-temperature degradation aged Y-TZP and Y-TZP-AL2O3

Friction, 2018
In this research, results of the investigation of the sliding friction and wear of yttria-stabilized tetragonal zirconia polycrystalline (Y-TZP) and Y-TZP-Al2O3 samples preliminarily subjected to low-temperature degradation are reported.
Nikolai L. Savchenko, Andrey V. Filippov, Sergei Yu Tarasov, Andrey I. Dmitriev, Evgeny V. Shilko, Aleksandr S. Grigoriev   +5 more
doaj   +1 more source

Concurrent strength and endurance training: the influence of dependent variable selection

, 2003
Twenty-six active university students were randomly allocated to resistance (R, n 5 9), endurance (E, n 5 8), and concurrent resistance and endurance (C, n 5 9) training con-ditions.
Leveritt, Michael, Barry, Ben, A. Logan, Peter, J. Abernethy, Peter   +3 more
core  

Lower Limb Strength and Balance in Adults with and without Down Syndrome

, 2020
Individuals with Down Syndrome demonstrate deficits in many physiological attributes, including muscular strength and balance. The purpose of this study was to examine the relationship between lower limb strength and balance in adults with and without ...
Harris, Natalie
core