Results 61 to 70 of about 388,695 (254)

Comprehensive Performance Evaluation of C Class Fly Ash Stability and Activity Index Based on Projection Pursuit Regression

Buildings
To better evaluate the comprehensive performance of Class C fly ash (FA) in terms of soundness and mechanical strength for engineering applications, this study analyzes the effects of CaO and free-CaO (f-CaO) on the strength activity index and soundness ...
Xiangzhi Kong, Miaomiao Gong, Mingshan Chen, Jingwei Gong, Liting Jia, Liqun Yang, Yiyi Wang   +6 more
doaj   +1 more source

Nutritional status and handgrip strength in elderly living at low human development index community

Medicina, 2014
Design of the study: Epidemiological cross-sectional population-based household study. Objective: To investigate the relationship between anthropometric indicators of nutritional status and muscular strength in community-dwelling elderly with low human ...
Bruno M. Queiroz, Raildo S. Coqueiro, Ludmila Schettino, Rafael Pereira, Marcos H. Fernandes, Aline R. Barbosa   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

A comparative study of handgrip strength among sedentary and non-sedentary workers

National Journal of Physiology, Pharmacy and Pharmacology, 2017
Background: India is a developing country with a rapid transformation in lifestyle including inappropriate diet and inadequate physical activity. More the physical activity greater will be the muscle strength.
Ahrsia Valavoor Fathima, Aswini R Dutt, Shankar K Bhat, Bhima Bhat, Ahris Valavoor Fakruddin   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults: A cross-sectional study from UK Biobank

Experimental Gerontology
Objectives: To investigate the associations of n-3 fatty acid intake with handgrip strength and muscle mass indices in older adults. A secondary aim was to investigate whether these associations differed by physical activity status. Research methods &
Abdulrahman T. Alsowail, Marion T. Guerrero Wyss, Frederick K. Ho, Carlos Celis-Morales, Stuart R. Gray   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Handgrip and contralateral knee flexion strength as key predictors of daily physical activity in severe knee osteoarthritis

Journal of Experimental Orthopaedics
Purpose In this study, factors associated with physical activity in patients with end‐stage knee osteoarthritis were investigated using a high‐precision wearable monitor.
Daisuke Urashima, Tomofumi Kinoshita, Tatsuhiko Kutsuna, Kunihiko Watamori, Takashi Tsuda, Yusuke Horita, Kazunori Hino, Masaki Takao   +7 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source