Results 51 to 60 of about 326,175 (263)

On the Strength Calculation of the Rotating parts

Procedia Chemistry, 2014
AbstractThe existing solutions of differential equations of equilibrium of an infinitesimal element of the rotating parts of an isotropic elastic solid known as the Navier equilibrium equations are considered. Examples of the flat disk calculation by solving the differential equilibrium equations by the sweep method and the finite element method in the
Belyaev, Vasiliy Mikhailovich, Zurilin, A. A., Cherkasov, S. O.   +2 more
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Structural design and model testing of the stator for a superconducting synchronous condenser with high-voltage XLPE cable windings

Zhejiang dianli
Using XLPE （cross-linked polyethylene） cables as stator windings in a superconducting synchronous condenser can significantly increase its voltage rating and enable direct grid connection.
ZHANG Jiancheng, GE Baojun, XIAO Shiyong, HUA Wen, SHI Junjun, CHEN Wei, SHEN Haocong   +6 more
doaj   +1 more source

Optimization of conditions for the formation of functional coatings based on carboxymethylcellulose with chromium [PDF]

ITM Web of Conferences
The possibility of increasing the strength and improving the functional properties of coatings based on biopolymers by adding metal powders is considered.
Antonova Natalia, Khokhlova Anna
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Research of the Calculation Method of Bending Strength of Non-orthogonal Helical Face Gear

Jixie chuandong, 2020
There is no analytical calculation method and formula for the calculation of the bending strength of the face gear.For this reason，based on the principle of tooth surface contact analysis，the formula for calculating the length of the bending arm is ...
Derun Qin, Long Yang, Jinyuan Tang, Siyu Chen   +3 more
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Static Strength Analysis and Test of Articulated Equipment of Suspended Modular Tram with 5 Modules

机车电传动, 2021
Tests and  finite element calculation methods were used to verify the structure and strength of the articulated equipment of the suspended modular tram with 5 modules and low  floor.
Xiongfang DENG, Baoming AN, Yuezhong CHEN   +2 more
doaj  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source