Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Optimization of conditions for the formation of functional coatings based on carboxymethylcellulose with chromium [PDF]
ITM Web of ConferencesThe possibility of increasing the strength and improving the functional properties of coatings based on biopolymers by adding metal powders is considered.
Antonova Natalia, Khokhlova Anna
doaj +1 more source
On the Strength Calculation of the Rotating parts
Procedia Chemistry, 2014 AbstractThe existing solutions of differential equations of equilibrium of an infinitesimal element of the rotating parts of an isotropic elastic solid known as the Navier equilibrium equations are considered. Examples of the flat disk calculation by solving the differential equilibrium equations by the sweep method and the finite element method in the
Belyaev, Vasiliy Mikhailovich +2 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Research of the Calculation Method of Bending Strength of Non-orthogonal Helical Face Gear
Jixie chuandong, 2020 There is no analytical calculation method and formula for the calculation of the bending strength of the face gear.For this reason，based on the principle of tooth surface contact analysis，the formula for calculating the length of the bending arm is ...
Derun Qin +3 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Static Strength Analysis and Test of Articulated Equipment of Suspended Modular Tram with 5 Modules
机车电传动, 2021 Tests and finite element calculation methods were used to verify the structure and strength of the articulated equipment of the suspended modular tram with 5 modules and low floor.
Xiongfang DENG +2 more
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Fracture Analysis and Fatigue Strength Calculation of Anchor Bolt Used in Circulating Water Pump in Nuclear Power Plant. [PDF]
Scanning, 2021 Chen Q, Zu S, Che Y, Feng D, Li Y.
europepmc +1 more source