Results 71 to 80 of about 347,905 (307)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Measuring implementation strength: Literature review draft report 2012 [PDF]

, 2012
Measuring implementation strength (sometimes referred to as implementation intensity) is an important programme evaluation process which helps to understand why some programmes are successful and some fail, attribute outcomes to a programme, and ...
Schellenberg, JA, Bobrova, N, Avan, BI
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Static Strength Analysis and Test of Articulated Equipment of Suspended Modular Tram with 5 Modules

机车电传动, 2021
Tests and  finite element calculation methods were used to verify the structure and strength of the articulated equipment of the suspended modular tram with 5 modules and low  floor.
Xiongfang DENG, Baoming AN, Yuezhong CHEN   +2 more
doaj  

Fatigue strength and durability analysis by normalised equivalent stress functionals

, 2003
Generalised fatigue durability diagrams are considered for a material under multi-axial loading given by a (non-regularly) oscillating function of time.
Mikhailov, SE, Sergey E. Mikhailov, Namestnikova, IV, Inna V. Namestnikova   +3 more
core  

Analysis on the hull girder ultimate strength of a bulk carrier using simplified method based on an incremental-iterative approach

, 2008
The hull girder ultimate strength of a typical bulk carrier is analyzed using a simplified method based on an incremental-iterative approach. First, vertical bending moment is examined by seven different methods.
Barltrop, Nigel, Ozguc, Ozgur
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

On the Strength Calculation of Shaft Bracket

Journal of Zosen Kiokai, 1947
Mr. A. W. Johns states in the T. I. N. A. of 1907 that stress induced by centrifugal force T originating in unbalance of propeller is greatest and gives the value of the maximum bending moment at that time, but in this paper, the value of the bending moment is scrutinized a little further, and farthermore, the value of the twisting moment, shearing ...
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source