Results 61 to 70 of about 230,180 (265)

Modified true triaxial Hoek-Brown criterion considering intermediate principal stress effect

Meitan kexue jishu
In order to improve the Hoek-Brown strength criterion not considering the influence of intermediate principal stress on rock strength, the evolutions of rock strength were investigated according to the results of the rock true triaxial compression test ...
Yapeng LI, Xiaosuo WU, Qiang ZHANG, Binsong JIANG   +3 more
doaj   +1 more source

Comparative Analyses Concerning Triaxial Compressive Yield Criteria of Coal with the Presence of Pore Water

Geofluids, 2020
The least absolute deviation is used as a metric to analyze the applicability of five yield criteria, to describe the yield characteristics of coal based on triaxial compressive strength tests on natural, water-saturated, and seepage coal samples with ...
Rulin Liu, Yanbin Yu, Weimin Cheng, Qingfeng Xu, Haotian Yang, Jialong Shen   +5 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Three-dimensional limit equilibrium method for rock slopes by constructing normal stress distribution over sliding surface and its application

Yantu gongcheng xuebao
The researches on the three-dimensional stability of rock slopes are of important theoretical significance and engineering application prospect. The conventional equivalent Mohr-Coulomb strength parameters used to analyze the stability of rock slopes ...
LU Kunlin 1, MEI Yifan 1, WANG Linfei 2, JIA Senlin 1, QIN Tao 1, ZHU Dayong 3
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Empirical Shear Strength Criterion for Artificial Joint

IOP Conference Series: Earth and Environmental Science, 2019
Abstract An accurate understanding of shear strength in joints is critical to effective geotechnical engineering. The complete rock shear test continues to shear after shear strength reaches it speak value, resulting in the appearance of a softening stage and a residual stage.
Ran Tan, Junrui Chai, Cheng Cao
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Macro-meso failure mechanism and strength criterion of frozen weakly cemented sandstone under triaxial unloading

Frontiers in Earth Science
IntroductionIn the excavation engineering of tunnels and mines in the western cold region, the unloading failure zone is mainly caused by stress release.
Qinghai Deng, Hao Fu, Junchao Wang, Xiaobiao An, Xianzhou Lyu   +4 more
doaj   +1 more source

A new strength criterion for structured soils

Journal of Rock Mechanics and Geotechnical Engineering, 2013
AbstractExisting strength criteria are mostly formulated to describe the mechanical properties of reconstituted soils. However, the engineering characteristics of structured soils are different from those of reconstituted soils in many aspects, especially in their strength properties.
Liu, Enlong, Nie, Qing, Zhang, Jianhai
openaire   +1 more source