Results 81 to 90 of about 2,401,267 (288)
On Sober's Criterion of Contrastive Testability [PDF]
, 2010 Elliott Sober has suggested his criterion of contrastive testability as an improvement over previous criteria of empirical significance like falsifiability.
Lutz, Sebastian
core
An Improved True Triaxial Hoek–Brown Strength Criterion
工程科学与技术, 2023 Hoek–Brown strength criterion has been widely used in rock and rock mechanics analysis, rock slope stability analysis, rock tunnel design, and other fields, but the conventional Hoek–Brown strength criterion does not consider the influence of ...
Xiangchao SHI +4 more
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
EMPIRICAL STRENGTH CRITERION OF COMPOSITE MATERIALS
Advanced Engineering Research, 2010 Empirical long-term strength criterion in terms of limit stress for constructive polymer materials considering ageing factor is found. The criterion corresponds to the type of Goldenblat - Kopnov.
O.G. OSYAEV
doaj
Evaluation of Strength Model Under Deep Formations with High Temperature and High Pressure
BuildingsElevated thermal conditions, rock formations exhibit distinct mechanical behaviors that significantly deviate from their characteristics under ambient temperature environments.
Fei Gao +3 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Reliability analysis of mechanical components containing random flaws [PDF]
, 2006 The goal of structural reliability is to assure that a structure adequately performs its intended function when operating under specified environmental conditions.
Iacopino, G.
core +3 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source