Results 61 to 70 of about 1,104,488 (305)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Exponential true triaxial strength criteria for rock

Yantu gongcheng xuebao, 2018
The rock strength is the premise and foundation for stability evaluation of rock engineering and optimization design of structures. Based on the true triaxial test results, the evolution of rock strength are analyzed: (1) The rock strength increases with
ZHANG Qiang , LI Cheng , GUO Qiang , MIN Ming , JIANG Bin-song , WANG Yan-ning
doaj   +1 more source

Synchronization on community networks

, 2006
In this Letter, we propose a growing network model that can generate scale-free networks with a tunable community strength. The community strength, $C$, is directly measured by the ratio of the number of external edges to internal ones; a smaller $C ...
Acebrón, Albert, Barabási, Barahona, Bing-Hong Wang, Boccaletti, Chavez, Chavez, Dorogovtsev, Gade, Gade, Gang Yan, Girvan, Guanrong Chen, Hasegawa, Heagy, Hong, Krapivsky, Kuramoto, Liu, Manrubia, McGraw, Ming Zhao, Newman, Nishikawa, Oh, Palla, Park, Pecora, Pecora, Pikovsky, Radicchi, Strogatz, Tao Zhou, Wang, Wang, Watts, Wu, Wu, Yan, Zhao, Zhao, Zhao, Zhou, Zhou   +44 more
core   +1 more source

Strength criterion and temperature dependent strength model of metallic glasses

International Journal of Solids and Structures, 2019
Abstract In this paper, the different fracture mechanisms of bulk metallic glasses in tension and compression are investigated through combining its macroscopic fracture behaviors and unique atomic structure. It is found that the compressive fracture process of metallic glasses should be mainly controlled by the shear progress.
Xianhe Zhang, Weiguo Li, Yong Deng, Jiaxing Shao, Xuyao Zhang, Liming Chen   +5 more
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Three-dimensional strength criterion for transverse isotropic geomaterials

Yantu gongcheng xuebao, 2018
The strength characteristic of the transverse isotropic soil include two aspects. On one hand, the strength curves are not symmetric around the three principal stress axes on deviatoric plane.
LU De-chun , LIANG Jing-yu , WANG Guo-sheng , DU Xiu-li
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Large-scale true triaxial tests on strength characteristics of coarse-grained soils

Yantu gongcheng xuebao, 2018
In order to obtain the strength evolution of coarse-grained soils under three-dimensional stress conditions, a series of true triaxial tests under different intermediate principal stress ratios (also called b value) are conducted for a kind of sandstone ...
JIANG Ji-wei , PAN Jia-jun , CHENG Zhan-lin , ZUO Yong-zhen , XU Han
doaj   +1 more source

Dynamical correlation functions and the quantum Rabi model

, 2013
We study the quantum Rabi model within the framework of the analytical solution developed in Phys. Rev. Lett. 107,100401 (2011). In particular, through time-dependent correlation functions, we give a quantitative criterion for classifying two regions of ...
Braak, Daniel, Kollar, Marcus, Romero, Guillermo, Solano, Enrique, Vallone, Fabio, Wolf, F. Alexander   +5 more
core   +1 more source

Criterion for Generation of Winds from Magnetized Accretion Disks [PDF]

, 2001
An analytic model is proposed for non-radiating accretion flows accompanied by up or down winds in a global magnetic field. Physical quantities in this model solution are written in variable-separated forms, and their radial parts are simple power law ...
Blandford R. D., Fabian A. C., Honma F., Kaburaki O., Nakamura K. E., Osamu Kaburaki   +5 more
core   +2 more sources