Results 71 to 80 of about 2,401,267 (288)

Comprehensive compressive-tensile strength criterion for intact rock [PDF]

, 2012
This paper presents a strength criterion for intact rock, which can well describe triaxial test data under compressive or tensile stress state. The proposed criterion is defined in terms of three parameters.
Bineshian, Zahra, Ghazvinian, Abdolhadi, Bineshian, Hossein   +2 more
core   +1 more source

Three-dimensional limit equilibrium method for rock slopes by constructing normal stress distribution over sliding surface and its application

Yantu gongcheng xuebao
The researches on the three-dimensional stability of rock slopes are of important theoretical significance and engineering application prospect. The conventional equivalent Mohr-Coulomb strength parameters used to analyze the stability of rock slopes ...
LU Kunlin 1, MEI Yifan 1, WANG Linfei 2, JIA Senlin 1, QIN Tao 1, ZHU Dayong 3
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Modified true triaxial Hoek-Brown criterion considering intermediate principal stress effect

Meitan kexue jishu
In order to improve the Hoek-Brown strength criterion not considering the influence of intermediate principal stress on rock strength, the evolutions of rock strength were investigated according to the results of the rock true triaxial compression test ...
Yapeng LI, Xiaosuo WU, Qiang ZHANG, Binsong JIANG   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Acute and delayed effects of a resistance training session leading to muscular failure on mechanical, metabolic, and perceptual responses

, 2018
Párraga-Montilla, JA, García-Ramos, A, Castaño-Zambudio, A, Capelo-Ramírez, F, González-Hernández, JM, Cordero-Rodríguez, Y, and Jiménez-Reyes, P. Acute and delayed effects of a resistance training session leading to muscular failure on mechanical ...
Capelo Ramírez, Fernando, Cordero Rodríguez, Yaiza Adela, Párraga Montilla, Juan A, García Ramos, Amador, Castaño Zambudio, Adrián, Jiménez Reyes, Pedro, González Hernández, Jorge M   +6 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source