Results 71 to 80 of about 1,104,488 (305)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Modified true triaxial Hoek-Brown criterion considering intermediate principal stress effect

open access: yesMeitan kexue jishu
In order to improve the Hoek-Brown strength criterion not considering the influence of intermediate principal stress on rock strength, the evolutions of rock strength were investigated according to the results of the rock true triaxial compression test ...
Yapeng LI   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Three-dimensional limit equilibrium method for rock slopes by constructing normal stress distribution over sliding surface and its application

open access: yesYantu gongcheng xuebao
The researches on the three-dimensional stability of rock slopes are of important theoretical significance and engineering application prospect. The conventional equivalent Mohr-Coulomb strength parameters used to analyze the stability of rock slopes ...
LU Kunlin 1, MEI Yifan 1, WANG Linfei 2, JIA Senlin 1, QIN Tao 1, ZHU Dayong 3
doaj   +1 more source

Testing the Collective Properties of Small-World Networks through Roughness Scaling

open access: yes, 2003
Motivated by a fundamental synchronization problem in scalable parallel computing and by a recent criterion for ``mean-field'' synchronizability in interacting systems, we study the Edwards-Wilkinson model on two variations of a small-worldnetwork.
A. Barrat   +10 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Anderson Transition in Disordered Bilayer Graphene

open access: yes, 2010
Employing the Kernel Polynomial method (KPM), we study the electronic properties of the graphene bilayers in the presence of diagonal disorder, within the tight-binding approximation.
Amini, Mohsen   +3 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

An optimality criterion for sizing members of heated structures with temperature constraints [PDF]

open access: yes
A thermal optimality criterion is presented for sizing members of heated structures with multiple temperature constraints. The optimality criterion is similar to an existing optimality criterion for design of mechanically loaded structures with ...
Narayanaswami, R.   +2 more
core   +1 more source

Polymer adsorption on heterogeneous surfaces

open access: yes, 1998
The adsorption of a single ideal polymer chain on energetically heterogeneous and rough surfaces is investigated using a variational procedure introduced by Garel and Orland (Phys. Rev. B 55 (1997), 226). The mean polymer size is calculated perpendicular
Huber, Gregor, Vilgis, Thomas A.
core   +1 more source

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