Results 91 to 100 of about 249,859 (265)
Evaluation method for safety of concrete slab stress based on multi-axial strength criterion
Yantu gongcheng xuebaoThe concrete-faced rockfill dams (CFRDs) rely on the key impermeable structures, such as concrete slabs, for their safe operation. Ensuring the safety of the concrete slabs is of the utmost importance.
WANG Fang 1, LI Guoying 1, MI Zhankuan 1, FENG Yelin 2, HUANG Qingfu 2
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Rock strength criterion considering the effect of hydrostatic stress on lode angle effect
Energy Science & Engineering, 2019 Rock strength criterion is a basic subject in mining engineering and petroleum engineering. It has important guiding significances to the process of underground energy exploitation. Different rocks have different strength envelopes.
Zhenlong Song +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
AerospaceThe performance upgrading of stratospheric airships hinges on breakthroughs in the mechanical properties of envelope materials. As a multi-layer composite, the envelope’s load-bearing layer exhibits orthotropic and nonlinear mechanical behaviors owing to
Zhanbo Li, Yanchu Yang, Rong Cai, Tao Li
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Evaluation of Flexible Road Pavement Construction State Using Objective Strength Criteria
The Baltic Journal of Road and Bridge Engineering, 2007 This article illustrates that by means of our methodology for evaluation of state of flexible road pavement construction (RPC) it is possible with an adequate precision for practical purposes to measure the remaining resource of pavement construction ...
Saulius Butkevicius +3 more
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source