Results 41 to 50 of about 2,682,010 (187)

In Vivo Degradation Behavior of the Magnesium Alloy LANd442 in Rabbit Tibiae [PDF]

, 2011
In former studies the magnesium alloy LAE442 showed promising in vivo degradation behavior and biocompatibility. However, reproducibility might be enhanced by replacement of the rare earth composition metal "E" by only a single rare earth element ...
Reifenrath, Janin, Ullmann, Berit, Dziuba, Dina, Seitz, Jan-Marten, Dirk Bormann, Andrea Meyer-Lindenberg, Bormann, Dirk, Dina Dziuba, Meyer-Lindenberg, Andrea, Berit Ullmann, Janin Reifenrath, Jan-Marten Seitz   +11 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Simulation and analysis method for dynamic fatigue reliability of shovel stick for mining electric shovel

Meitan kexue jishu
In order to reduce the stick fracture caused by random load during the operation of the electric shovel in open-pit mines, a simulation and analysis method of the dynamic reliability of the stick of the electric shovel in the mining was proposed.
Zhiyuan SHI, Gang SHEN, Chong CHEN, Laiyu WEN   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Degradation-Based Reliability Analysis of Plunger-Pair Structure via Distribution Interference Theory

Lubricants
High-pressure plunger-cylinder pairs in axial piston pumps are prone to brittle failure due to local contact stress, time-dependent material degradation, and cyclic loading, which complicates long-term reliability assessment.
Yanjie Li, Lu Yao, Xintian Liu, Yao Cui, Zhaoqiang Wang   +4 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Macro–Mesoscopic Analysis and Parameter Calibration of Rock–Soil Strength Degradation Under Different Water Contents

Applied Sciences
Rainfall is a key triggering factor for numerous geotechnical hazards. Hence, it is necessary to investigate the degradation characteristics of rock–soil strength under different water contents.
Bo Yang, Shun Zhang, Zhixing Deng, Na Su, Shaopeng Chen, Di Zhu   +5 more
doaj   +1 more source

Static and cyclic p-y curves for laterally loaded piles in soft clay

Yantu gongcheng xuebao, 2017
A pseudo-three-dimensional analysis method on static p-y curves of laterally loaded piles in soft clay is conducted. This method is based on the two-dimensional elastic fictitious loading upper bound limit analysis approach considering the stress-strain ...
HUANG Mao-song 1, 2, MA Hao 1, 2, LI Sen 1, 2, YU Jian 1, 2, ZHANG Chen-rong 1, 2
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Mechanism of Strength Degradation of Fiber-Reinforced Soil Under Freeze–Thaw Conditions

Buildings
Understanding the mechanism of strength degradation in fiber-reinforced soils under freeze–thaw conditions is critical for expanding their engineering applications.
Xiaojuan Yu, Xingyu Wu, Peng Zhu, Chao Liu, Chengchun Qiu, Zhongbing Cai   +5 more
doaj   +1 more source