Results 51 to 60 of about 3,323,410 (297)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Severe Plastic Deformation of Mg–Zn–Zr–Ce Alloys: Advancing Corrosion Resistance and Mechanical Strength for Medical Applications

Metals, 2023
Magnesium-based alloys hold potential for medical applications, but face challenges like rapid bioresorption and limited mechanical strength during early bone healing.
Nikita Luginin, Anna Eroshenko, Margarita Khimich, Konstantin Prosolov, Alexander Kashin, Pavel Uvarkin, Alexey Tolmachev, Ivan Glukhov, Alexander Panfilov, Yurii Sharkeev   +9 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Strength of Materials [PDF]

Nature, 1957
Resistance of Materials By Prof. Fred B. Seely and Prof. James O. Smith. Fourth edition. Pp. xvi + 459. (New York: John Wiley and Sons, Inc.; London: Chapman and Hall, Ltd., 1956.) 52s. net.
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

On Temperature Dependence of Microstructure, Deformation Mechanisms and Tensile Properties in Austenitic Cr-Mn Steel with Ultrahigh Interstitial Content C + N = 1.9 Mass.%

Metals, 2020
The microstructure, deformation mechanisms, tensile properties and fracture micromechanisms of ultrahigh-interstitial austenitic Fe-22Cr-26Mn-1.3V-0.7C-1.2N (mass.%) steel were investigated in wide temperature interval.
Elena Astafurova, Sergey Astafurov, Galina Maier, Irina Tumbusova, Eugene Melnikov, Valentina Moskvina, Marina Panchenko, Kseniya Reunova, Nina Galchenko   +8 more
doaj   +1 more source

An Initial Assessment of Infiltration Material Selection for Selective Laser Sintered Preforms [PDF]

, 2004
High-temperature infiltration is an important process that is used to add strength to skeletal microstructures. In this study, particulate metal matrix composites (MMCs) are fabricated.
Barrow, Stacia L., Bourell, David, Evajs, Scott   +2 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Characterization of a Bimetallic Multilayered Composite “Stainless Steel/Copper” Fabricated with Wire-Feed Electron Beam Additive Manufacturing

Metals, 2021
The results of investigating the structure and properties of multilayered bimetallic “steel–copper” macrocomposite systems, obtained by wire-feed electron beam additive manufacturing, are presented in the paper.
Kseniya Osipovich, Andrey Vorontsov, Andrey Chumaevskii, Denis Gurianov, Nikolai Shamarin, Nikolai Savchenko, Evgeny Kolubaev   +6 more
doaj   +1 more source

High-temperature tensile tester for ceramics [PDF]

, 1974
Apparatus measures tensile strength of rigid, low-density ceramic materials at temperatures up to 1375 K. Tensile grips mate with tensile specimen and form top and bottom of lightweight furnace.
Smith, M.
core   +1 more source