Results 91 to 100 of about 3,758,516 (308)
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
, 2020 More than 40 agencies that fund health research capacity strengthening in low-and middle-income countries (LMICs) participate in the ESSENCE Health Research initiative, which has established a mechanism for reviewing and coordinating their funding. Taken
Aslanyan, Garry +11 more
core +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
工程科学学报, 2017 The new support way-square confined concrete (SQCC) arch in complex-condition underground engineering applications has higher supporting strength and post-bearing capacity.
WANG Qi +7 more
doaj +1 more source
High-pressure torsion of iron with various purity levels and validation of Hall-Petch strengthening mechanism [PDF]
, 2019 Impurity atoms have a significant effect on the strength of metals processed by severe plastic deformation (SPD), but their strengthening mechanism is still under argument.
Benito Páramo, José Antonio +4 more
core +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page +4 more
wiley +1 more source
Strengthening of law enforcement coordination mechanism is a requirement of development of the state [PDF]
, 2018 This article discusses the issues of further development and improvement of the existing mechanism of coordination of law enforcement activities in Uzbekistan, in particular, the strengthening of the vertical power with simultaneous concretization of ...
Mirzaev, Sh.
core
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley +1 more source
Legislative strengthening meets party support in international assistance: a closer relationship? [PDF]
, 2009 Recent reports recommend that international efforts to help strengthen legislatures in emerging democracies should work more closely with support for building stronger political parties and competitive party systems.
Burnell, Peter J.
core +1 more source