Results 81 to 90 of about 184,583 (305)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Investigation on the Strengthening and Toughening Mechanism of 500 MPa V-Nb Microalloyed Anti-Seismic Rebars [PDF]

, 2015
Two types of 500 MPa anti-seismic rebars were produced by V-Nb microalloyed combined with controlled rolling and cooling technology, the strengthening and toughening mechanism of which were investigated.
Weiqiang ZHANG, Yinhui YANG, Jianchun CAO, Min HUANG, Wei CHEN, Zhe SHI   +5 more
core   +1 more source

Research and application progress of high entropy alloy materials in laser additive repair

Journal of Aeronautical Materials
Introducing emerging high entropy alloys materials into advanced intelligent manufacturing for laser additive repair is expected to promote the deep integration of new generation of materials and manufacturing technology and greatly improve the ...
LI Zhanming, WANG Menglu, SUN Xiaofeng, WANG Rui, WANG Hongyu   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

High-pressure torsion of iron with various purity levels and validation of Hall-Petch strengthening mechanism [PDF]

, 2019
Impurity atoms have a significant effect on the strength of metals processed by severe plastic deformation (SPD), but their strengthening mechanism is still under argument.
Benito Páramo, José Antonio, Cabrera Marrero, José M., Edalati, Kaveh, Tejedor Busquets, Robert, Horita, Zenji   +4 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Mechanical properties and strengthening mechanism of medium and high volume fraction SiCp/Al composites

Cailiao gongcheng
The medium and high volume fraction SiCp/Al composites were prepared by hot isostatic pressing powder metallurgy process with volume fractions of 35%, 45% and 55% using 2024 and 6061 aluminum alloys as the matrix, respectively. The effect of matrix alloy
CUI Yan, LIAO Jiajie, CAO Leigang, YANG Yue   +3 more
doaj   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Research progress in additive manufacturing of AlCoCrFeNi2.1 eutectic high-entropy alloys

Cailiao gongcheng
AlCoCrFeNi2.1 eutectic high-entropy alloy is characterized by a fine, homogeneous, and regular lamellar structure, as well as good organizational structure and mechanical properties with both strength and plasticity over a wide range of temperature (70 ...
QIU Hefang, YUAN Xiaojing, LUO Weipeng, ZHANG Ze, CHENG Chen, CUI Fanfan   +5 more
doaj   +1 more source