Results 81 to 90 of about 694,109 (303)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Evolution of microstructure and properties of Cu-4.5 wt.% Ag alloy prepared by vacuum horizontal continuous casting in solid solution and aging treatment

open access: yesMaterials Research Express, 2020
The vacuum horizontal continuous casting method was used for preparing Cu-4.5 wt.% Ag alloy rod containing few oxygen. The evolution of microstructure was observed by metallographic microscope (OM), scanning electron microscope (SEM) and transmission ...
Linsheng Tang   +5 more
doaj   +1 more source

On broad iron K-alpha lines in Seyfert 1 galaxies

open access: yes, 1995
The X-ray spectrum obtained by Tanaka et al from a long observation of the active galaxy MCG$-6-30-15$ shows a broad iron K$\alpha$ line skewed to low energies.
Brandt, W. N.   +7 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Nanoscale α Phase Enables Excellent Strength–Ductility Balance in TC21 Titanium Alloy

open access: yesNanomaterials
The limited ductility of conventional titanium alloys significantly limits their application in critical load-bearing components. To overcome this limitation, a Ti-6Al-2Mo-2Nb-2Zr-2Sn titanium alloy (TC21) was subjected to warm rolling at 500 and 600 °C ...
Keyu Ma   +4 more
doaj   +1 more source

Strengthening mechanism and thermal deformation behavior of Al-12Si/Fe piston composite

open access: yesMaterials Research Express, 2020
The present paper aims the investigation on the influence of Fe based amorphous on strength of aluminum alloy (Al-12Si), and the thermal deformation behavior of new Al-12Si/Fe base amorphous composites. On this foundation, a heat flow stress model of the
Hao Yang   +4 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Synthesis, microstructure, and mechanical properties of in situ TiB2/Al-4.5Cu composites

open access: yesScience and Engineering of Composite Materials, 2018
In situ TiB2/Al-4.5Cu composites with different TiB2 particle amounts were fabricated by the salt-metal reaction technique. The effects of in situ TiB2 on the microstructure and mechanical properties of Al-4.5Cu alloy were studied in this paper.
Li Hongying   +3 more
doaj   +1 more source

Effect of different casting techniques on the microstructure and mechanical properties of AE44-2 magnesium alloy

open access: yesMaterials Research Express, 2020
AE44-2 magnesium (Mg) alloys were fabricated by gravity casting (GC), high pressure die casting (HPDC), and high vacuum assisted high pressure die casting (HVHPDC).
Taihe Le   +5 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

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