Results 111 to 120 of about 3,255,070 (396)

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Rate of isolation of streptococcus species from children with bacterial infections: an indication for introduction of streptococcal vaccines

Nigerian Journal of Paediatrics
Background: Streptococcus species are among the commonest bacterial causes of childhood morbidity in developing countries. Streptococcal diseases in children have not been as well characterized in Nigeria as it has been in industrialized countries.
Onalo R , Adeleke SI , Nwalorzie C , Njoku R   +3 more
doaj  

Streptococcal toxic shock syndrome in the intensive care unit

Annals of Intensive Care, 2018
The streptococcal toxic shock syndrome is a severe complication associated with invasive infections by group A streptococci. In spite of medical progresses in the care of patients with septic shock during the last decades, this condition has remained ...
Marylin Schmitz, Xavier Roux, Benedikt Huttner, Jérôme Pugin   +3 more
doaj   +1 more source

Group A streptococcal infections during the seasonal influenza outbreak 2010/11 in South East England.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2011
We present a series of 19 cases of invasive Group A streptococcal (iGAS) infection reported to the Thames Valley Health Protection Unit from 1 December 2010 to 15 January 2011. Ten patients died and a prodrome of influenza-like illness was reported in 14
J. Scaber, S. Saeed, C. Ihekweazu, A. Efstratiou, N. McCarthy, E. O'Moore   +5 more
semanticscholar   +1 more source

The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation

Advanced Science, EarlyView.
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng   +16 more
wiley   +1 more source

Clinical and Epidemiological Characteristic of Streptococcal tonsillitis in Organized Collectives

Эпидемиология и вакцинопрофилактика, 2017
Research objective. During identification and the analysis of clinical and epidemiological features of streptococcal tonsillitis in organized collectives to develop definition of a standard case of streptococcal tonsillitis. Materials and methods. In the
D. A. Zharkov, A. A. Kuzin, O. V. Mal'tsev, S. A. Svistunov, R. V. Nikolaev, G. G. Marin   +5 more
doaj   +1 more source

Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection. [PDF]

, 2019
Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis.
Barnard, Karen N, Bensing, Barbara A, Iverson, TM, Lebrilla, Carlito B, Li, Liang, Parrish, Colin R, Sullam, Paul M, Thomas, Wendy E, Wong, Maurice, Xiong, Yan, Yakovenko, Olga   +10 more
core   +3 more sources

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues

Advanced Science, EarlyView.
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan, Xin Xu, Lin Huang, Dan Li, Yiran Deng, Xiangfei Xue, Susu Guo, Yiman Huang, Xiao Zhang, Yongchun Yu, Lifang Ma, Kun Qian, Jiayi Wang   +12 more
wiley   +1 more source

Group A Streptococci-Associated Necrotizing Fasciitis following Cat Bite in an Immunocompromised Patient

Case Reports in Critical Care, 2017
Necrotizing soft tissue infections are characterized clinically by fulminant tissue destruction, systemic signs of toxicity, and high mortality. Accurate diagnosis and appropriate treatment must include early surgical intervention and antibiotic therapy.
Sudheer Nambiar, Asha Karippot, Joe Devasahayam, Tony Oliver   +3 more
doaj   +1 more source

Prevalence of gram-negative infections in cervico-facial sepsis [PDF]

, 2019
Magister Chirurgiae Dentium (MChD)In cervico-facial sepsis a substantial proportion of organisms are normally gram-negative staining of which the majority are anaerobes (Boyanova 2006 and Sanchez 2010).
Barnard, Neil
core