Results 51 to 60 of about 43,451 (311)

An age-of-infection model with both symptomatic and asymptomatic infections [PDF]

arXiv, 2021
We formulate a general age-of-infection epidemic model with two pathways: the symptomatic infections and the asymptomatic infections. We then calculate the basic reproduction number $\mathcal{R}_0$ and establish the final size relation. It is shown that the ratio of accumulated counts of symptomatic patients and asymptomatic patients is determined by ...
arxiv  

3D Microtumors Representing Ovarian Cancer Minimal Residual Disease Respond to the Fatty Acid Oxidation Inhibitor Perhexiline

Advanced Healthcare Materials, EarlyView.
Minimal residual disease (MRD) leads to cancer relapse and poor survival in ovarian cancer. The lack of representative 3D models limits therapy development. The microfluidics‐based high throughput 3D microtumor platform described here generates clinically‐relevant MRD models. The 3D microtumors recapitulate the molecular signatures of MRD from patients.
Xingyun Yang, Mara Artibani, Yongcheng Jin, Aneesh Aggarwal, Yujia Zhang, Sandra Muñoz‐Galvan, Ellina Mikhailova, Lena Rai, Nobina Mukherjee, Ravinash Krishna Kumar, Ashwag Albukhari, Shaohua Ma, Linna Zhou, Ahmed Ashour Ahmed, Hagan Bayley   +14 more
wiley   +1 more source

Infancy narcolepsy: Streptococcus infection as a causal factor

Sleep Science, 2015
Streptococcal infections are suggested as a risk factor for narcolepsy. This hypothesis is supported by the presence of anti-streptolysin antibodies in 65% of patients with narcolepsy.
Danielle Antunes Lopes, Fernando Morgadinho Santos Coelho, Marcia Pradella-Hallinan, Maria Helena de Araújo Melo, Sergio Tufik   +4 more
doaj   +1 more source

Micro‐ and Nano‐Bots for Infection Control

Advanced Materials, EarlyView.
This review presents a strategic vision for integrating micro‐ and nanobots in the pipeline for infection diagnosis, prevention, and treatment. To develop these robots as a practical solution for infection management, their design principles are clarified based on their propulsion mechanisms and then categorized infection management domains based on ...
Azin Rashidy Ahmady, Shadman Khan, Hong Han, Wei Gao, Zeinab Hosseinidoust, Tohid F. Didar   +5 more
wiley   +1 more source

Therapeutic Potential of Manuka Honey Microbubble Dressing in Wound Management

Advanced Materials Interfaces, EarlyView.
The manuka honey microbubble dressing innovation utilizes high‐density stainless steel mesh technology to generate microscopic honey bubbles achieving S. aureus elimination by fine‐tuning factors such as microbubble size, MH microbubble consumption, and treatment duration. This pioneering approach transforms traditional wound healing and may reduce the
Pei‐Ju Lin
wiley   +1 more source

Streptococcal Toxic-Shock Syndrome: Spectrum of Disease, Pathogenesis, and New Concepts in Treatment

Emerging Infectious Diseases, 1995
Since the 1980s there has been a marked increase in the recognition and reporting of highly invasive group A streptococcal infections with or without necrotizing fasciitis associated with shock and organ failure.
Dennis L. Stevens
doaj   +1 more source

Spatially dense stochastic epidemic models with infection-age dependent infectivity [PDF]

arXiv, 2023
We study an individual-based stochastic spatial epidemic model where the number of locations and the number of individuals at each location both grow to infinity. Each individual is associated with a random infection-age dependent infectivity function. Individuals are infected through interactions across the locations with heterogeneous effects.
arxiv  

Antagonist Targeting the Species‐Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti‐H. pylori Infection

Advanced Science, EarlyView.
This study demonstrates that the atypical dehydrogenase/isomerase FabX in Type‐II fatty acid biosynthesis pathway is essential for H. pylori infection by retaining unsaturated fatty acid synthesis and producing superoxide (ROS). A small molecule FBX‐1991 that specifically targets FabX to inhibit H.
Lin Zhang, Xiaoxue Ruan, Xudong Hang, Ding Heng, Chang Cai, Liping Zeng, Guoxin Zhang, Lu Zhou, Hongkai Bi, Liang Zhang   +9 more
wiley   +1 more source

Autosomal recessive hyper‐IgE syndrome due to DOCK8 deficiency: An adjunctive role for omalizumab

Journal of Cutaneous Immunology and Allergy, Volume 5, Issue 6, Page 222-226, December 2022., 2022
We report a rare case of AR‐HIES with DOCK8 deficiency in a young male that was successfully treated by infection management, skincare, diet elimination, and omalizumab. Abstract Autosomal recessive hyper‐IgE syndrome (AR‐HIES) is a rare primary immunodeficiency disorder characterized by high serum IgE levels, recurrent viral skin infections, severe ...
Kim Han Nguyen, Quynh Anh Nguyen, Mai Hoang Tran, Thu Thuy Can, Mai Thi Vu, Nam Sy Vo, Hieu Chu Chi, Sheryl van Nunen, Dinh Van Nguyen   +8 more
wiley   +1 more source

Invasive Group A Streptococcal Infection in High School Football Players, New York City, 2003

Emerging Infectious Diseases, 2005
After being notified that 2 high school football teammates were hospitalized with confirmed or suspected invasive group A streptococcal infections, we conducted an investigation of possible spread among other team members. This investigation highlights a
Susan E. Manning, Elsie Lee, Maribeth Bambino, Joel Ackelsberg, Don Weiss, Chiminyan Sathyakumar, John Kornblum, Oxiris Barbot, Dwight Johnson, Edward L. Kaplan, Marcelle Layton   +10 more
doaj   +1 more source