Results 71 to 80 of about 7,428 (223)

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Pharmacokinetic Analysis of Intravenous Push Cefepime in Critically Ill Patients With Sepsis

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 6, June 2026.
ABSTRACT Background Intravenous push (IVP) administration of cefepime increases ease of preparation and limits the need for small volume parenterals. The data on IVP pharmacokinetic/pharmacodynamic (PK/PD) parameters are limited, but may be especially relevant in critically ill patients with altered PK/PD for time‐dependent antibiotics like cefepime ...
Susan E. Smith, Rehana Bagodiya, Phuong Luong, Sakshi Shinde, Christopher M. Bland, Christopher Barry, Michael G. Bartlett, Nicholas R. Fox, Trisha N. Branan   +8 more
wiley   +1 more source

Old Bug—New Challenges After COVID-19 Pandemic: Severe Invasive Streptococcus pyogenes Infections in Adults—A Single-Center Experience in Poland

Pathogens
Since the beginning of December 2022, an unusually high number of cases and deaths of Group A Streptococcus (GAS) infections has been reported in many European countries.
Patrycja Leśnik, Jarosław Janc, Martyna Biała, Marzenna Bartoszewicz, Lidia Łysenko, Natalia Słabisz   +5 more
doaj   +1 more source

Bacterial Phenotype Variants in Group B Streptococcal Toxic Shock Syndrome

Emerging Infectious Diseases, 2009
We conducted genetic and functional analyses of isolates from a patient with group B streptococcal (GBS) necrotizing fasciitis and toxic shock syndrome.
Parham Sendi, Linda Johansson, Samira Dahesh, Nina M. Van Sorge, Jessica Darenberg, Mari Norgren, Jan Sjölin, Victor Nizet, Anna Norrby-Teglund   +8 more
doaj   +1 more source

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang, Ngasin Lam, Xiaoming Huang, Yang Jiao   +3 more
wiley   +1 more source

Full‐Length 16S and 18S rRNA Long‐Read Sequencing Reveals Gut Microbiome Diversity in the European Brown Hare (Lepus europaeus)

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Full‐length 16S and 18S rRNA Oxford Nanopore sequencing of large intestine contents from 30 healthy European brown hares revealed broad gut microbiome diversity. An 80% identity threshold detected substantially greater taxonomic richness than 95%, emphasizing the value of long‐read sequencing in wildlife microbiome research. ABSTRACT The European brown
Zbigniew Bełkot, Mateusz G. Adamski, Zuzanna J. Strzałkowska, Ewa D. Domańska, Daria Kłosińska, Grzegorz Kunstman, Dawid Skoczek, Joanna Pławińska‐Czarnak   +7 more
wiley   +1 more source

S1 Guideline on Infected Interdigital Intertrigo (also called Gram‐Negative Toe Web Infection)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 832-843, June 2026.
Summary Infected interdigital intertrigo is an exudative, macerating, mixed infection of the toe webs in which gram‐negative bacteria (Pseudomonas aeruginosa and Enterobacterales) seem prevalent, but in which gram‐positive pathogens (Staphylococcus [S.] aureus, streptococci, enterococci) and fungi (dermatophytes, yeasts) also occur.
Christoph Zeyen, Dietrich Abeck, Karsten Becker, Joachim Dissemond, Birgit Kahle, Hans Peter Lorenzen, Bettina Löffler, Andreas Maier‐Hasselmann, Till Mittank‐Weidner, Alexander Nast, Cord Sunderkötter   +10 more
wiley   +1 more source

Refractory Toxic Shock-Like Syndrome from Streptococcus dysgalactiae ssp. equisimilis and Intravenous Immunoglobulin as Salvage Therapy: A Case Series

Case Reports in Infectious Diseases, 2016
Infections from Streptococcus dysgalactiae ssp. equisimilis (SDSE) can cause a wide variety of infections, ranging from mild cellulitis to invasive disease, such as endocarditis and streptococcal toxic shock-like syndrome (TSLS).
Marjan Islam, Dennis Karter, Jerry Altshuler, Diana Altshuler, David Schwartz, Gianluca Torregrossa   +5 more
doaj   +1 more source

Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid

Case Reports in Infectious Diseases, 2017
Necrotizing fasciitis is a deep-seated subcutaneous tissue infection that is commonly associated with streptococcal toxic shock syndrome (TSS). Surgical debridement plus penicillin and clindamycin are the current standard of care.
Hana Rac, Karine D. Bojikian, Jose Lucar, Katie E. Barber   +3 more
doaj   +1 more source

Group A Streptococcus Septic Shock after Surgical Abortion: A Case Report and Review of the Literature

Case Reports in Obstetrics and Gynecology, 2017
Group A Streptococcus (GAS) causing puerperal sepsis is a leading cause of maternal mortality worldwide. Although rare, GAS infection is a relatively significant public health concern because of its propensity to evolve rapidly into septic shock ...
Stephanie C. Tardieu, Elizabeth Schmidt
doaj   +1 more source