Results 101 to 110 of about 493,919 (312)

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo [PDF]

, 2012
Lipoproteins are an important class of surface associated proteins that have diverse roles and frequently are involved in the virulence of bacterial pathogens.
Hermans Peter W. M., Brown, J.S., Durmort Claire, Jeremy S. Brown, Jonathan M Cohen, Emilie Camberlein, Hermans, P.W.M., Camberlein Emilie, Durmort, C, Vernet Thierry, MacDonald, N, Chimalapati, S, Claire Durmort, Jeremy S Brown, Timothy Mitchell, Suneeta Chimalapati, Cohen, J.M., Camberlein, E, Peter W. M. Hermans, Brown, JS, Chimalapati, S., Hermans, PWM, Vernet, T., Chimalapati Suneeta, Camberlein, E., Mitchell, T., Mitchell Timothy, MacDonald, N., Peter W M Hermans, Nathanael MacDonald, Thierry Vernet, Vernet, T, Cohen, JM, Cohen Jonathan M., Brown Jeremy S., MacDonald Nathanael, Durmort, C., Jonathan M. Cohen, Mitchell, T   +38 more
core   +2 more sources

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Pan-cancer analysis reveals intratumoral microbial diversity in multiple cancers by amplicon technology

Frontiers in Cellular and Infection Microbiology
Despite numerous studies investigating intratumoral microorganisms and their significant roles in cancer initiation, progression, and treatment efficacy, a systematic understanding of intratumoral microorganisms remains lacking.
Xudong Liu, Xudong Liu, Yuteng Yao, Aoyi Xiao, Dingyan Cao, Jingheng Zhang, Yanan Shi, Qing Zhong, Zilong He, Zilong He, Wenming Wu, Wenming Wu   +11 more
doaj   +1 more source

Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection [PDF]

, 2015
The authors would like to thank the Horserace Betting Levy Board for funding the analysis of the eqbE mutant (ref: Vet/prj/758). The Horse Trust funded the collection of isolates from UK outbreaks of strangles (G1606).
Paillot, Romain, Waller, Andrew S, Steward, Karen F, Robinson, Carl, Holden, Matthew T G, Harris, Simon R, Parkhill, Julian, Webb, Katy S, Holden, Matthew T G; id_orcid   +8 more
core   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

The effects of probiotics intervention on oral health outcomes: a comprehensive umbrella review of meta-analyses

Frontiers in Oral Health
BackgroundProbiotics are proposed adjuncts for oral health, but findings from meta-analyses are inconsistent. We conducted an umbrella review of meta-analyses to synthesize evidence on probiotics’ effects on cariogenic bacteria such as Streptococus (S ...
Zhen Tang, Yunzhen Deng, Gang Guo, LiLi Zhou   +3 more
doaj   +1 more source

Activation of silent gal genes in the lac-gal regulon of Streptococcus thermophilus [PDF]

, 2001
Streptococcus thermophilus strain CNRZ 302 is unable to ferment galactose, neither that generated intracellularly by lactose hydrolysis nor the free sugar.
Vos, W.M., de, Kuipers, Oscar P.; id_orcid, Kuipers, Oscar P., Bogaard, Patrick T.C. van den, Vaughan, Elaine E., Bogaard, P.T.C., van den, Vaughan, E.E., Kuipers, O.P., Vos, Willem M. de, Catzeddu, Pasquale, Catzeddu, P.   +10 more
core   +1 more source

Liquid Gallium Nanozyme Coatings Enable Sustained Nitric Oxide Generation With Antioxidant and Anti‐Inflammatory Functions

Advanced Science, EarlyView.
Liquid gallium (Ga) acts as a catalytic center for nitric oxide (NO) generation within a tannic acid–zirconium metal–phenolic network coating. Stabilized Ga nanoparticles catalyze S‐nitrosothiol decomposition through surface electron transfer, enabling controlled NO production, enhancing endothelial biocompatibility, and providing antioxidant and anti ...
Franco Centurion, Kang Lin, Shu Geng, Siti Nur Asyura Adzlan, Qingqing Fan, Federico Mazur, Ravindra Kokate, Priyank Kumar, Christina Cortez‐Jugo, Frank Caruso, Rona Chandrawati   +10 more
wiley   +1 more source

Clinico-microbiological analysis of streptococcal isolates from blood cultures with focus on infective endocarditis

Journal of Current Research in Scientific Medicine
Background: Infective endocarditis (IE) is an infection of the endocardium, most commonly caused by Streptococcus. The study aims to evaluate the clinical features, blood culture yields, species distribution, and antibiotic susceptibility patterns of ...
T. Vaishali, Sridevi Dinakaran, K. Sandhya Bhat   +2 more
doaj   +1 more source