Results 31 to 40 of about 407,256 (265)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

FATAL GROUP A STREPTOCOCCAL TOXIC SHOCK-LIKE SYNDROME IN A CHILD WITH VARICELLA: REPORT OF THE FIRST WELL DOCUMENTED CASE WITH DETECTION OF THE GENETIC SEQUENCES THAT CODE FOR EXOTOXINS SPE A AND B, IN SÃO PAULO, BRAZIL

Revista do Instituto de Medicina Tropical de São Paulo, 1999
A previously healthy seven-year-old boy was admitted to the intensive care unit because of toxaemia associated with varicella. He rapidly developed shock and multisystem organ failure associated with the appearance of a deep-seated soft tissue infection ...
Jaques SZTAJNBOK, Marguerite LOVGREN, Maria Cristina C. BRANDILEONE, Paulo C.F. MAROTTO, James A. TALBOT, Antonio C. SEGURO   +5 more
doaj  

Group B Streptococcus maternal colonization and neonatal sepsis in Belgium between 2012 and 2021: a description of the epidemiological situation and identification of risk factors

BMC Pregnancy and Childbirth
Background Group B Streptococcus (GBS) infection is a leading cause of neonatal morbidity. Maternal rectovaginal GBS colonization is a primary risk factor for early onset neonatal GBS infection. In Belgium, pregnant women are screened and, if positive or
Zsófia Bognár, Charlotte Leroy, Virginie Van Leeuw, Régine Goemaes, Pierrette Melin, Cécile Meex, Rosalie Sacheli, Fleur Camfferman, Amber Litzroth, Frederik De Keersmaeker, Laura Cornelissen   +10 more
doaj   +1 more source

Virulence factors of Streptococcus agalactiae relating to neonatal sepsis

Journal of Medical and Scientific Research
Streptococcus agalactiae (Group B Streptococcus, GBS) infection is the leading cause of disease in neonates. Infection in the neonate can occur via vertical transmission or ascension through the vaginal tract.
Angela Benton, Melissa Wedeman, Ava Toluie   +2 more
doaj   +1 more source

Investigation of in vitro Mineral Forming Bacterial Isolates from Subgingival Calculus

Archives of Clinical and Experimental Surgery, 2014
The mechanism that dictates the formation of dental calculus, an important component of periodontal health, has yet to be sufficiently explained. The effect of bacterial flora on dental calculus formation is important for periodontal status.
Turgut Demir, Ozlem Baris, Esra Zor
doaj   +1 more source

Association of Novel Streptococcus sanguinis Virulence Factors With Pathogenesis in a Native Valve Infective Endocarditis Model

Frontiers in Microbiology, 2020
Streptococcus sanguinis (S. sanguinis) is an abundant oral commensal which can cause disseminated human infection if it gains access to the bloodstream. The most important among these diseases is infective endocarditis (IE). While virulence phenotypes of
Anthony M. Martini, Bridget S. Moricz, Allison K. Ripperger, Phuong M. Tran, Molly E. Sharp, Ana N. Forsythe, Katarina Kulhankova, Wilmara Salgado-Pabón, Bradley D. Jones, Bradley D. Jones   +9 more
doaj   +1 more source

Microbiologic characterisation of bacterial infections in children with atopic dermatitis

Southern African Journal of Infectious Diseases, 2022
Background: Patients with atopic dermatitis (AD), the commonest chronic inflammatory skin disease are often colonised and infected by Staphylococcus aureus.
Nkosinathi O. Zwane, Josiah T. Masuka, Antoinette V. Chateau, Anisa Mosam   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Lung abscess in immunocompromised

Galicia Clínica, 2020
We present the case of a 44-year-old man, construction worker, hypertensive, smoker, with rheumatoid arthritis under prednisolone 10mg/day for 10 months. Gingival crevice disease. The patient was referred to the Emergency Department after 5 days of right
Teresa Margarida Dias Moreira, Ligía Rodrigues dos Santos   +1 more
doaj   +1 more source