Results 61 to 70 of about 407,256 (265)

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Heme-Mediated Selection of Encapsulated Streptococcus pneumoniae in the Lungs by Oxidative Stress [PDF]

, 2023
Babek Alibayov, Anna Scasny, Ana G. Jop Vidal, Landon Murin, Sandy M. Wong, Kristin Edwards, Zehava Eichembaun, Tracy Punshon, Brian P. Jackson, Marie-Thérèse Hopp, Larry S. McDaniel, Brian J. Akerley, Diana Imhof, Jorge E. Vidal   +13 more
openalex   +1 more source

Bone‐Derived dECM Hydrogels Support Tunable Microenvironments for In Vitro Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Minne Dekker, Luke Hipwood, Akhilandeshwari Ravichandran, Dietmar W. Hutmacher, Christoph Meinert, Jacqui McGovern   +5 more
wiley   +1 more source

Pan-cancer analysis reveals intratumoral microbial diversity in multiple cancers by amplicon technology

Frontiers in Cellular and Infection Microbiology
Despite numerous studies investigating intratumoral microorganisms and their significant roles in cancer initiation, progression, and treatment efficacy, a systematic understanding of intratumoral microorganisms remains lacking.
Xudong Liu, Xudong Liu, Yuteng Yao, Aoyi Xiao, Dingyan Cao, Jingheng Zhang, Yanan Shi, Qing Zhong, Zilong He, Zilong He, Wenming Wu, Wenming Wu   +11 more
doaj   +1 more source

Circuitry Rewiring Directly Couples Competence to Predation in the Gut Dweller Streptococcus salivarius

Cell Reports, 2018
Summary: Small distortions in transcriptional networks might lead to drastic phenotypical changes, especially in cellular developmental programs such as competence for natural transformation.
Johann Mignolet, Laetitia Fontaine, Andrea Sass, Catherine Nannan, Jacques Mahillon, Tom Coenye, Pascal Hols   +6 more
doaj   +1 more source

Effect of 2D and 3D ECM and Biomechanical Cues on Human iPSC‐Derived Liver Progenitor Cell Differentiation

Advanced Healthcare Materials, EarlyView.
An engineered microtissue model is developed and optimized to investigate human liver development. Extracellular matrix composition and mechanical forces are tuned using high‐throughput assays. Human induced pluripotent stem cells serve as the cellular source, enabling the observation of de novo patterned differentiation.
Ishita Jain, Brock Grenci, Hyeon Ryoo, Yang Yuan, Salman R. Khetani, Gregory H. Underhill   +5 more
wiley   +1 more source

Blood Culture Negative Endocarditis: A Review of Laboratory Diagnostic Approaches

International Journal of General Medicine, 2023
Kuan-Pei Lin,1 Ting-Kuang Yeh,1,2 Yu-Chuan Chuang,1 Li-An Wang,1 Yun-Ching Fu,3,4,* Po-Yu Liu1,4– 6,* 1Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 2Genomic Center for ...
Lin KP, Yeh TK, Chuang YC, Wang LA, Fu YC, Liu PY   +5 more
doaj  

Competence in Streptococcus pneumoniae and Close Commensal Relatives: Mechanisms and Implications

Frontiers in Cellular and Infection Microbiology, 2019
The mitis group of streptococci comprises species that are common colonizers of the naso-oral-pharyngeal tract of humans. Streptococcus pneumoniae and Streptococcus mitis are close relatives and share ~60–80% of orthologous genes, but still present ...
Gabriela Salvadori, Roger Junges, Donald A. Morrison, Fernanda C. Petersen   +3 more
doaj   +1 more source

Biologically Active Implants Prevent Mortality in a Mouse Sepsis Model

Advanced Healthcare Materials, EarlyView.
A modular, triple‐action titanium implant is developed to prevent implant‐associated infections by repelling bacteria, killing pathogens, and enhancing tissue integration. Coatings with phage cocktails targeting P. aeruginosa and S. aureus show significant bacterial reduction and improved survival in a mouse sepsis model.
Martin Stark, Fereshteh Bayat, Sara Rahmani, Mathura Thirugnanasampanthar, Taylor Kramer, Elise Schwarz, David Wilson, Jeffrey I. Weitz, Zeinab Hosseinidoust, Tohid F. Didar   +9 more
wiley   +1 more source

Lemierre’s syndrome: A rare complication of acute bacterial pharyngitis

Southern African Journal of Infectious Diseases
Lemierre’s syndrome is a rare clinical syndrome of septic thrombophlebitis following a bacterial oropharyngeal infection. Lemierre’s syndrome can be difficult to recognise and has significant morbidity.
Pierre Joubert, Muhammed S. Moosa
doaj   +1 more source