Results 61 to 70 of about 480,499 (310)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Potentially virulence-related extracellular proteins of Streptococcus equi [PDF]

, 2006
Equine strangles, a disease of the upper respiratory tract caused by the bacterium Streptococcus equi subspecies equi, is one of the most commonly diagnosed and serious diseases in horses. However, the molecular basis of S. equi subsp.
Lannergård, Jonas
core   +1 more source

Investigation of in vitro Mineral Forming Bacterial Isolates from Subgingival Calculus

Archives of Clinical and Experimental Surgery, 2014
The mechanism that dictates the formation of dental calculus, an important component of periodontal health, has yet to be sufficiently explained. The effect of bacterial flora on dental calculus formation is important for periodontal status.
Turgut Demir, Ozlem Baris, Esra Zor
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

FATAL GROUP A STREPTOCOCCAL TOXIC SHOCK-LIKE SYNDROME IN A CHILD WITH VARICELLA: REPORT OF THE FIRST WELL DOCUMENTED CASE WITH DETECTION OF THE GENETIC SEQUENCES THAT CODE FOR EXOTOXINS SPE A AND B, IN SÃO PAULO, BRAZIL

Revista do Instituto de Medicina Tropical de São Paulo, 1999
A previously healthy seven-year-old boy was admitted to the intensive care unit because of toxaemia associated with varicella. He rapidly developed shock and multisystem organ failure associated with the appearance of a deep-seated soft tissue infection ...
Jaques SZTAJNBOK, Marguerite LOVGREN, Maria Cristina C. BRANDILEONE, Paulo C.F. MAROTTO, James A. TALBOT, Antonio C. SEGURO   +5 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Group B Streptococcus maternal colonization and neonatal sepsis in Belgium between 2012 and 2021: a description of the epidemiological situation and identification of risk factors

BMC Pregnancy and Childbirth
Background Group B Streptococcus (GBS) infection is a leading cause of neonatal morbidity. Maternal rectovaginal GBS colonization is a primary risk factor for early onset neonatal GBS infection. In Belgium, pregnant women are screened and, if positive or
Zsófia Bognár, Charlotte Leroy, Virginie Van Leeuw, Régine Goemaes, Pierrette Melin, Cécile Meex, Rosalie Sacheli, Fleur Camfferman, Amber Litzroth, Frederik De Keersmaeker, Laura Cornelissen   +10 more
doaj   +1 more source

Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis. [PDF]

, 2015
Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S.
Schultsz, C, Langford, P.R., Maglennon, Gareth A, Campbell, J., Wang, J., Chieu, T.T.B., Tran, TBC, Wren, B.W., Hoa, N.T., Tucker, Alexander W, Corander, Jukka, Corander, J., Ngo Thi, H, Schultsz, Constance, Valimaki, N, Wren, BW, Schultsz, C., Farrar, Jeremy, Holden, M T G, Wren, B W, Baker, S., Peters, Sarah E., Wang, Jinhong, Jombart, T., Maskell, DJ, Cuccui, Jon, Vehkala, Minna, Chaudhuri, RR, Chieu, TTB, Campbell, James, Rycroft, Andrew N, Campbell, J, Weinert, Lucy A, Wren, Brendan W, BRaDP1T Consortium, Chaudhuri, R R, Wang, J, Chaudhuri, Roy R, Terra, Vanessa, Chieu, Tran Thi Bich, Baig, Abiyad, Rycroft, A N, Nguyen, VVC, Howell, Kate J, Parkhill, Julian, Maskell, D J, Bentley, S D, Chaudhuri, R.R., Chau, N.V.V., Howell, Kate J., Baker, Stephen, Valimaki, N., Jombart, Thibaut, Baker, S, Ngo Thi Hoa, Tucker, AW, Weinert, LA, Ngo, TH, Baig, A., Peters, S.E., Rycroft, A.N., Tucker, A.W., Holden, Matthew T G, Tucker, Alexander W., Chau, Nguyen Van Vinh, Howell, K.J., Peters, SE, Vehkala, M, Parkhill, J, Matthews, Dominic, Vehkala, M., Peters, S E, Bentley, Stephen D, Harris, D., Langford, PR, Chaudhuri, Roy R., Bentley, Stephen D., Holden, Matthew T. G., Tran Thi Bich Chieu, Nguyen, Van Vinh Chau, Baig, A, Farrar, J, Corander, J, Li, Yanwen, Langford, Paul R, Holden, M.T.G., Weinert, Lucy A., Bosse, Janine T, Jombart, T, Välimäki, Niko, Bentley, S.D., Holden, MTG, Tran, Thi Bich Chieu, Maskell, Duncan J, Hoa, NT, Rycroft, Andrew N., Rycroft, AN, Tucker, A W, Maskell, Duncan J., Langford, Paul R., Bentley, SD, Peters, Sarah E, Holden, Matthew TG, Howell, K J, Farrar, J., Parkhill, J., Wren, Brendan W., Weinert, L.A., Nguyen Van Vinh Chau, Maskell, D.J., BRaDP1T Consortium,, Hoa, Ngo Thi, Van Vinh Chau, Nguyen, Weinert, L A, Howell, KJ, Nguyen Van Vinh, C, Harris, D, Langford, P R, Van Vinh Chau, N, Harris, David, Tran Thi Bich, C, Vaelimaeki, N   +121 more
core   +6 more sources

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Determination of Certain Immunological and Physicochemical Features of Pneumococcal Surface Protein A (PspA): In-silico Cloning of pspA [PDF]

Modern Medicine
Objective: Pneumococcal surface protein A (PspA) is present in almost all strains of pneumococci and is highly immunogenic, stimulating the production of antibodies. It has a role in pneumococcal pathogenicity.
Enass Waad AL-HADIDI, Ali Adel DAWOOD
doaj   +1 more source