Results 11 to 20 of about 304,728 (296)

Artificial Intelligence-Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae. [PDF]

Adv Sci (Weinh)
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Fitch JS, Ariadi MD, Kwun MJ, Howells L, Hernandez-Hernandez S, Croucher NJ, Ballester PJ.   +6 more
europepmc   +2 more sources

Pneumonia and Streptococcus pneumoniae vaccine [PDF]

Archives of Pharmacal Research, 2017
Pneumonia is an inflammatory disease of the lung, responsible for high morbidity and mortality worldwide. It is caused by bacteria, viruses, fungi, or other microorganisms. Streptococcus pneumoniae, a gram-positive bacterium with over 90 serotypes, is the most common causative agent.
Kim, Gyu-Lee, Seon, Seung-Han, Rhee, Dong-Kwon   +2 more
openaire   +2 more sources

Streptococcus pneumoniae [PDF]

Journal of Microbiology, Immunology and Infection, 2015
El neumococo, Streptococcus pneumoniae, es un microorganismo patógeno capaz de causar en humanos diversas infecciones y procesos invasivos severos. Se trata de una bacteria Gram positiva , que presenta una forma oval y el extremo distal lanceolado. Es inmóvil, no forma endosporas, y es un miembro alfa-hemolítico del género Streptococcus.
Martínez Robleto, María Lisvania, Ortiz Espinoza, Gustavo Adolfo   +1 more
  +5 more sources

Comparison of Molecular Method and Culture in Detection of Community Acquired Pneumonia in Under Five Year Children in Assam, India [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Pneumonia is the single largest infectious cause of death in children worldwide. Aetiology of pneumonia can be identified using multiple diagnostic tools including culture, serology and Polymerase Chain Reaction (PCR); common pathogens ...
Aparna Sonowal, Partha Pratim Das, Mithu Medhi, Aditi Baruah, Ezaz Hussain   +4 more
doaj   +1 more source

Lysogeny in Streptococcus pneumoniae [PDF]

Microorganisms, 2020
Bacterial viruses, or bacteriophages, are major contributors to the evolution, pathogenesis and overall biology of their host bacteria. During their life cycle, temperate bacteriophages form stable associations with their host by integrating into the chromosome, a process called lysogeny.
Geneviève Garriss, Birgitta Henriques-Normark   +1 more
openaire   +5 more sources

Evaluation of Immulex S. pneumoniae Omni test for the direct detection of S. pneumoniae from positive blood cultures

Heliyon, 2023
Rapid and early identification of Streptococcus pneumoniae from positive blood cultures is crucial for the management of patients with bloodstream infections (BSI).
Mohammed Suleiman, Nazik Elamin, Rhanty Nabor, Jill Roberts, Patrick Tang, Mohammad Rubayet Hasan, Andrés Pérez-López   +6 more
doaj   +1 more source

A plasmid in Streptococcus pneumoniae [PDF]

Journal of Bacteriology, 1979
Plasmid deoxyribonucleic acid has been detected in three related laboratory strains of Streptococcus pneumoniae. Strains D39S, R36, and R36NC each contain a minimum of two copies per cell of a 2.0-megadalton plasmid (pDP1). A plasmid twice as large as this smaller one is also present in much lower quantity in these strains, but neither plasmid is ...
M D, Smith, W R, Guild
openaire   +2 more sources

Increased lethality of respiratory infection by Streptococcus pneumoniae in the Dp16 mouse model of Down syndrome

FASEB BioAdvances, 2023
Objectives We sought to investigate whether the Dp16 mouse model of Down syndrome (DS) is more susceptible to severe and lethal respiratory tract infection by Streptococcus pneumoniae.
Kelley L. Colvin, Robert J. Elliott, Desiree M. Goodman, Julie Harral, Edward G. Barrett, Michael E. Yeager   +5 more
doaj   +1 more source

The impact of specific and non-specific immunity on the ecology of Streptococcus pneumoniae and the implications for vaccination [PDF]

, 2013
More than 90 capsular serotypes of Streptococcus pneumoniae coexist despite competing for nasopharyngeal carriage and a gradient in fitness. The underlying mechanisms for this are poorly understood and make assessment of the likely population impact of ...
Robertson, Charles, Edmunds, W. John, Flasche, Stefan, Goldblatt, David, Yoon Hong, Choi, Miller, Elizabeth   +5 more
core   +5 more sources

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source