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The Streptococcus pyogenes vaccine landscape
npj Vaccines, 2023 Recent efforts have re-invigorated the Streptococcus pyogenes (Group A Streptococcus) vaccine development field, though scientific, regulatory and commercial barriers persist, and the vaccine pipeline remains sparse.
Donald R. Walkinshaw +5 more
semanticscholar +4 more sources
Nature Communications, 2023 A variant of group A Streptococcus serotype M1 (UK) has been increasingly reported and can be differentiated from the global variant by its overexpression of the superantigen SpeA.
Mark R Davies +2 more
exaly +2 more sources
Streptococcus pyogenes balanoposthitis
IDCases, 2020 The main causative organism of balanoposthitis in sexually active adolescents is reportedly the group B hemolytic streptococcus. While cases of balanoposthitis caused by group A streptococcal infection in children have been reported, their occurrence in ...
Yuta Norimatsu, Yuki Ohno
doaj +4 more sources
CRISPR-Cas in Streptococcus pyogenes [PDF]
RNA Biology, 2019 The discovery and characterization of the prokaryotic CRISPR-Cas immune system has led to a revolution in genome editing and engineering technologies. Despite the fact that most applications emerged after the discovery of the type II-A CRISPR-Cas9 system
Anaïs Le Rhun +3 more
semanticscholar +3 more sources
The Bacteriophages of Streptococcus pyogenes
Microbiology Spectrum, 2019 The bacteriophages of Streptococcus pyogenes (group A streptococcus) play a key role in population shaping, genetic transfer, and virulence of this bacterial pathogen.
W. McShan +2 more
semanticscholar +3 more sources
Asymptomatic carriage of Streptococcus pyogenes among school children in Sana’a city, Yemen
BMC Research Notes, 2019 Objectives Streptococcus pyogenes is the most frequent cause of pharyngitis and skin infections in children. It is also the causative agent of dangerous immune-complications such as rheumatic fever and rheumatic heart disease which are common in Yemen ...
Arwa Mohammed Othman +3 more
doaj +2 more sources
Restricted Sequence Variation in
mSphere, 2020 A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding protein (PBP) PBP2x. To determine whether this is an isolated case or reflects a broader prevalence of mutations that might ...
Andrew Hayes +4 more
doaj +2 more sources
Platelet aggregation by Streptococcus pyogenes [PDF]
Infection and Immunity, 1983 Heat-killed group A Streptococcus pyogenes induced platelet aggregation in platelet-rich plasma. Aggregation was dependent upon the ratio of platelets to bacteria, with maximal aggregation occurring at 0.8 platelets per bacterium (final concentration, 300,000 per microliter).
Gretchen Kurpiewski +3 more
openalex +4 more sources
Streptococcus pyogenes adhesion and colonization [PDF]
FEBS Letters, 2016 Streptococcus pyogenes (group A Streptococcus, GAS) is a human‐adapted pathogen responsible for a wide spectrum of disease. GAS can cause relatively mild illnesses, such as strep throat or impetigo, and less frequent but severe life‐threatening diseases ...
Stephan Brouwer +4 more
semanticscholar +6 more sources
BMC Genomics, 2019 Background The human pathogen Streptococcus pyogenes, or group A Streptococcus, is responsible for mild infections to life-threatening diseases. To facilitate the characterization of regulatory networks involved in the adaptation of this pathogen to its ...
Isabelle Rosinski-Chupin +4 more
doaj +2 more sources