Results 101 to 110 of about 343,019 (395)

Horizontal DNA transfer mechanisms of bacteria as weapons of intragenomic conflict [PDF]

, 2016
Horizontal DNA transfer (HDT) is a pervasive mechanism of diversification in many microbial species, but its primary evolutionary role remains controversial.
A Adams, A Adams, AB Dalia, AI Khan, B Martin, BJ Haijema, BR Levin, C Boutry, C Buchrieser, C Camacho, C Canchaya, C Chewapreecha, C Fraser, C Johnston, C Johnston, C Johnston, Christophe Fraser, Christopher Wymant, CS Wylie, D Dubnau, D Hyatt, DA Baltrus, DA Caugant, DA Higgins, DA Morrison, DA Morrison, DE Fouts, DJP Engelmoer, E Borezee, E Szathmáry, E V Pestova, E Zaccaria, EA Campbell, EJ Feil, EJ Gaasbeek, EJ Gaasbeek, EP Rocha, ES Antonova, F Ginetti, F Griffith, F Liu, GG Wilson, GJ Stewart, GM Süel, GW Goldberg, H Bagci, H Bernstein, H Deveau, H Li, H Maamar, H Muller, H Ochman, H Tong, H-H Chou, HC Neu, I Chen, I Mortier-Barriere, I Mortier-Barrière, J Bondy-Denomy, J Guglielmini, J Majewski, J Majewski, J-P Claverys, JA Lanie, JA Londoño-Vallejo, JA Mongold, JC Lefevre, JC Mell, JH Stuy, JJ Sakamoto, JK Setlow, JM Auchtung, JM Musser, JM Smith, JM Smith, JO McInerney, JP Claverys, JP Claverys, JT Simpson, JW Beaber, K Turgay, KS Makarova, KT Konstantinidis, L Attaiech, L Fontaine, L Van Valen, L-M Bobay, LP Macfadyen, LS Frost, LS Håvarstein, LS Håvarstein, M Berge, M Boetzer, M Del Grosso, M Prudhomme, M Ramirez, MA Hoelzer, ME Kahn, MF Wojciechowski, MJ Lopez-Sanchez, ML Gwinn, MR Oggioni, MS Dorer, MTG Holden, Nicholas J. Croucher, Nick H. Barton, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, NJ Croucher, O Johnsborg, OE Cornejo, OH Ambur, OT Avery, P Glaser, P Jorth, P Luo, PA Levin, Paul Turner, PJ Johnsen, R Davidoff-Abelson, R Edgar, R Mostowy, RA Fisher, Rafal Mostowy, RE Michod, RE Yasbin, RJ Redfield, RJ Redfield, RJ Redfield, RJ Redfield, RJ Redfield, RJ Redfield, RK Aziz, RP Novick, S Lacks, SA McMahon, SB Beres, SE Finkel, SJ Labrie, SP Otto, Stephen D. Bentley, T Carver, T Nozawa, U Munoz-Najar, WA Sweetman, WJ Kent, X Charpentier, X Charpentier, X Didelot, Y Li, Z Zhou   +157 more
core   +3 more sources

Direct Detection of Streptococcus suis from Cerebrospinal Fluid, Positive Hemoculture, and Simultaneous Differentiation of Serotypes 1, 1/2, 2, and 14 within Single Reaction

Pathogens, 2021
Streptococcus suis is an emerging zoonotic bacterium causing septicemia and meningitis in humans. Due to rapid disease progression, high mortality rate, and many underdiagnosed cases by time-consuming routine identification methods, alternative ...
Ingyin Shun Lae Thu, K. Tragoolpua, S. Intorasoot, Usanee Anukool, P. Khamnoi, Anusak Kerdsin, C. S. Tharinjaroen   +6 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

PK-PD Integration Modeling and Cutoff Value of Florfenicol against Streptococcus suis in Pigs

Frontiers in Pharmacology, 2018
The aims of the present study were to establish optimal doses and provide an alternate COPD for florfenicol against Streptococcus suis based on pharmacokinetic-pharmacodynamic integration modeling.
Zhixin Lei, Zhixin Lei, Zhixin Lei, Qianying Liu, Qianying Liu, Shuaike Yang, Shuaike Yang, Bing Yang, Bing Yang, Haseeb Khaliq, Kun Li, Kun Li, Saeed Ahmed, Saeed Ahmed, Abdul Sajid, Abdul Sajid, Bingzhou Zhang, Pin Chen, Pin Chen, Yinsheng Qiu, Jiyue Cao, Jiyue Cao, Qigai He   +22 more
doaj   +1 more source

Sub-MIC Tylosin Inhibits Streptococcus suis Biofilm Formation and Results in Differential Protein Expression [PDF]

, 2016
Streptococcus suis (S. suis) is a crucial zoonotic pathogen which causes severe diseases in humans and pigs. Biofilms of S. suis can induce persistent infections which are harder to treat.
Chang Wang, Honghai Zhao, Jianqing Chen, Jingwen Bai, Shuai Wang, Yanbei Yang, Yanhua Li, Yonghui Zhou, Yulin Zhao   +8 more
core   +2 more sources

Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14**

Angewandte Chemie, 2021
Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S.
Shuo Zhang, Mauro Sella, Julinton Sianturi, Patricia Priegue, Dacheng Shen, P. Seeberger   +5 more
semanticscholar   +1 more source

Streptococcus suisinfections in birds [PDF]

Avian Pathology, 1994
Four cases of Streptococcus suis infection were diagnosed in psittacine birds and four others in zebrafinches, bullfinches, canaries and a duck. The main clinical and pathological manifestation was septicaemia with multiple sudden deaths in nestlings, young and adults. Other cases were solitary, with evidence for secondary involvement of S. suis.
L A, Devriese, F, Haesebrouck, P, de Herdt, P, Dom, R, Ducatelle, M, Desmidt, S, Messier, R, Higgins   +7 more
openaire   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Rapid detection of zoonotic Streptococcus suis serotype 2 and 14 by enzyme-activated probe fluorescence quantitative PCR method

BMC Veterinary Research
Streptococcus suis serotypes 2 and 14 are the most common zoonotic strains, but previous identification methods made distinguish these two serotypes from other S. suis serotypes difficult.
Yaxing Su, Jiajia Meng, Mingwei Zhao, Chunling Li, Shaolun Zhai, Yan Li, Pinpin Chu, Zhibiao Bian, Kunli Zhang, Dongxia Yang, Zhiyong Jiang, Hongchao Gou, Chenggang Xu   +12 more
doaj   +1 more source

Human Case of Streptococcus suis Serotype 16 Infection

Emerging Infectious Diseases, 2008
Streptococcus suis infection is an emerging zoonosis in Southeast Asia. We report a fatal case of S. suis serotype 16 infection in a Vietnamese man in 2001.
Ho Dang Trung Nghia, Ngo Thi Hoa, Le Dieu Linh, James Campbell, To Song Diep, Nguyen Van Vinh Chau, Nguyen Thi Hoang Mai, Tran Tinh Hien, Brian G. Spratt, Jeremy Farrar, Constance Schultsz   +10 more
doaj   +1 more source