Results 101 to 110 of about 78,983 (258)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Machine‐Learning Analysis of Streptomyces coelicolor Transcriptomes Reveals a Transcription Regulatory Network Encompassing Biosynthetic Gene Clusters

Advanced Science
Streptomyces produces diverse secondary metabolites of biopharmaceutical importance, yet the rate of biosynthesis of these metabolites is often hampered by complex transcriptional regulation.
Yongjae Lee, Donghui Choe, Bernhard O. Palsson, Byung‐Kwan Cho   +3 more
doaj   +1 more source

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

PROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima, Wilson Dias Segura, Leonardo Brogliato de Moraes, Reinaldo Souza Oliveira, Pedro Henrique Corteletti Manfio, Alison Felipe Alencar Chaves, Wagner Luiz Batista   +6 more
wiley   +1 more source

STREPTOMYCES LAVENDULAE AND STREPTOMYCES VENEZUELAE [PDF]

Journal of Bacteriology, 1958
openaire   +2 more sources

Herbaria as repositories of past soil properties and historical soil DNA

PLANTS, PEOPLE, PLANET, EarlyView.
Soil health is fundamental to agriculture, food security, and the sustainable management of terrestrial ecosystems under ongoing climate and land‐use changes. Soil microorganisms play a key role in these processes, yet how soils and their microbial communities have changed over time in response to global environmental change remains poorly understood ...
Gianluca Grasso, Régis Debruyne, Martino Adamo, Eva Perez Pimparé, Olivier Rué, Naoise Nunan, Valeria Bianciotto, Roland Marmeisse   +7 more
wiley   +1 more source

Combined application of Bacillus velezensis JDB15 and Trichoderma harzianum JDL4 suppresses banana Fusarium wilt under controlled conditions

Pest Management Science, EarlyView.
The surfactin C secreted by JDB15 and the probable parasitism of JDL4 lead to the leakage of intracellular macromolecules and the degradation of hyphae, respectively. Combined application of the two strains effectively controls banana Fusarium wilt under controlled conditions.
Deng Chen, Minghao Ju, Hongyang Li, Junting Feng, Xueyong Zi, Xuqian Gong, Yida Che, Xiaoya Lei, Zihuan Geng, Hongsen Deng, Kang Zhao, Jianghui Xie, Xiao‐Lin Chen, Jun Peng   +13 more
wiley   +1 more source

Controlled incubation, leachate, and pot assays of shrimp shell‐based compost for suppressing Verticillium dahliae in olive

Pest Management Science, EarlyView.
Shrimp shell compost suppresses Verticillium dahliae microsclerotia, enhances chitinase activity, lowers olive wilt severity and improves plant recovery under controlled conditions. Abstract BACKGROUND Verticillium wilt of olive (Olea europaea L.), caused by Verticillium dahliae Kleb., is difficult to manage because long‐lived microsclerotia persist in
Gharbi Yaakoub, Bouazizi Emna, Hayet Hfayeth, Triki Mohamed Ali   +3 more
wiley   +1 more source

Biocontrol and plant growth‐promoting potential of Streptomyces strains against fungal pathogens of tomato and wheat for a sustainable agriculture

Pest Management Science, EarlyView.
This study highlights the biocontrol potential of Streptomyces strain Strep_22. In vitro, it inhibits key fungal pathogens by 91.52%. In vivo, it significantly reduces disease incidence in wheat and tomato while enhancing biomass, shoot, and root development, offering a highly promising, sustainable ecological alternative to chemical pesticides ...
Thomas Conte, Maria Grazia Morea, Gaetana Ricciardi, Angelo Pastino, Francesco Lops, Maria Luisa Raimondo, Antonia Carlucci   +6 more
wiley   +1 more source

UV mutagenesis‐enhanced Streptomyces nogalater produces a novel streptothricin‐like compound with strong activity against cabbage soft rot

Pest Management Science, EarlyView.
UV mutagenesis of Streptomyces sp. KRA0514‐6 yielded HL‐3, a novel streptothricin‐like compound (C17H29N7O8) with N‐methylglycine replacing β‐lysine, achieving 100% cabbage soft rot control at >1 ppm concentration. Abstract BACKGROUND A total of 1000 soil‐derived actinomycetes were isolated and screened for antibacterial activity against Pectobacterium
Young Sook Kim, Mirjalol Umurzokov, Hae Young Kim, Chun‐Zhi Jin, Eun Ae Kim, Kwang Min Cho   +5 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source