Results 141 to 150 of about 38,235 (184)

A Semester-Long Laboratory in Molecular Biology and Biochemistry Focusing on the Discovery of Novel β-Lactamase Inhibitors From Streptomyces. [PDF]

Biochem Mol Biol Educ
Gordon MT, Ratnayake RMMN, Rexford AM, Butcher RA.   +3 more
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Inter-species horizontal transfer of biosynthetic gene clusters: an evolutionary driver for chemical diversity in bacterial communities. [PDF]

Essays Biochem
Zotchev SB.
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Expanding perspectives on specialized metabolism in Streptomyces bacteria. [PDF]

Essays Biochem
Tiller LA, McCoy Bridges KP, Hindra, Elliot MA.   +3 more
europepmc   +1 more source

Investigating the genome complexity of Streptomyces clavuligerus [PDF]

, 2020
Streptomyces clavuligerus is the producer of clavulanic acid; a β-lactamase inhibitor that isused in combination with the antibiotic amoxicillin to treat many bacterial infections. The unique genome of S.
Gallardo, Lis Algora
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Ammonium repression of cephalosporin production by Streptomyces clavuligerus

Canadian Journal of Microbiology, 1985
Production of β-lactam antibiotics took place during growth of Streptomyces clavuligerus in chemically defined medium. The specific activities of isopenicillin N synthetase ("cyclase"), isopenicillin N epimerase, and deacetoxycephalosporin C synthetase ("expandase") increased during the exponential phase of growth.
A F, Braña, S, Wolfe, A L, Demain
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Cephamycin Production by Streptomyces Clavuligerus

1991
The classical β-lactam antibiotics can be divided into hydrophobic and hydrophilic fermentation products. The hydrophobic members, e.g. benzylpenicillin (penicillin G) and phenoxymethylpenicillin (penicillin V), contain non-polar side chains, e.g. phenylacetate and phenoxyacetate, respectively, and are made only by filamentous fungi; the best known of ...
A. L. Demain, J. M. Piret
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Improvement for the production of clavulanic acid by mutant Streptomyces clavuligerus

Letters in Applied Microbiology, 2002
To improve the production of clavulanic acid through the development of strains, the selection of a production medium and a pH shift strategy in a bioreactor.Streptomyces clavuligerus mutant 15 was selected by antibacterial activities. As a result of pH control in a 2.5 l bioreactor, the highest productivity (3.37 microg x ml(-1) x h(-1)) was obtained ...
S D, Lee, S W, Park, K K, Oh, S I, Hong, S W, Kim   +4 more
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Kinetic analysis of cephalosporin biosynthesis in Streptomyces clavuligerus

Biotechnology and Bioengineering, 1991
AbstractA kinetic model describing the cephalosporin biosynthesis in Streptomyces clavuligerus was developed. Using previously reported kinetic data of biosynthetic enzymes, we examined the kinetics of cephalosporin production. The predicted time profile of the specific production rate during a batch culture parallels that of experimental observation ...
L H, Malmberg, W S, Hu
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Lysine catabolism and α-aminoadipate synthesis in Streptomyces clavuligerus

Applied Microbiology and Biotechnology, 1991
The intracellular α-aminoadipic acid pool in Streptomyces glavuligerus mycelium growing in a starch-peptone medium decreased during the late exponential and stationary phases when cephamycin was being produced; however, the amino acid accumulated extracellularly.
K, Madduri, S, Shapiro, A C, Demarco, R L, White, C, Stuttard, L C, Vining   +5 more
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Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus

Applied Microbiology and Biotechnology, 2013
Holomycin is a member of the dithiolopyrrolone class of secondary metabolites. It contains a cromophore formed by two heterocycles, one of them carrying a disulfide bridge. The holomycin chromophore is also present in thioluthin, aureothricin, the xenorhabdins and the complex thiomarinols.
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