Results 111 to 120 of about 686,138 (265)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Streptomycin Biosynthesis and Metabolism

, 1970
Margaret S. Walker, James B. Walker
openalex   +1 more source

Streptomyces griseus Streptomycin Phosphotransferase: Expression of Its Gene in Escherichia coli and Sequence Homology with Other Antibiotic Phosphotransferases and with Eukaryotic Protein Kinases [PDF]

, 1989
Chang‐Kweng Lim, Margaret C. M. Smith, J. Petty, S. Baumberg, John C. Wootton   +4 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Promotion and inhibition of mutation in pathogens

Russian Open Medical Journal, 2014
This paper presents the research findings of a sequence of three experiments that were used to assess the impact of a cell’s stage in its life cycle on mutatability and its possible mechanism. The first experiment consisted of a modified fluctuation test
Maurice Samuel Devaraj
doaj  

Partial Inhibition of Polysomal Ribosomes of Escherichia coli by Streptomycin

, 1973
Brian Wallace, Phang C. Tai, Eugene L. Herzog, Bernard D. Davis   +3 more
openalex   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Comparison of Salmonella enterica Serovar Typhimurium Colitis in Germfree Mice and Mice Pretreated with Streptomycin

, 2005
Bärbel Stecher, Andrew J. Macpherson, Siegfried Hapfelmeier, Marcus Kremer, Thomas Stallmach, Wolf‐Dietrich Hardt   +5 more
openalex   +1 more source

The Role of Spontaneous Variants in the Acquisition of Streptomycin Resistance by the Shigellae [PDF]

, 1946
Morton Klein, Leonard J. Kimmelman
openalex   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source