Results 101 to 110 of about 8,779 (217)

Semaglutide slows the progression of cognitive impairment and pathological changes in the hippocampus in a model of Alzheimer's disease

open access: yesНеврология, нейропсихиатрия, психосоматика
Currently, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are considered promising drugs for the treatment of Alzheimer's disease (AD) and other neurodegenerative diseases due to their complex mechanism of action, which includes (in addition to ...
A. K. Pavlova   +7 more
doaj   +1 more source

Anti-diabetic effects of Amygdalus lycioides spach in streptozocin-induced diabetic rats [PDF]

open access: yes, 2018
Diabetes mellitus is a group of metabolic disorders characterized by elevated blood sugar and abnormalities in insulin secretion and action. There are many anti-diabetic plants, which might supply useful sources for developing new medicines that can be ...
Arshadi,, S. S.   +4 more
core  

Streptozocin and o,p'DDD in the treatment of adrenocortical cancer patients : long-term survival in its adjuvant use [PDF]

open access: yes, 2000
BACKGROUND:To evaluate the efficacy of streptozocin and o.p'DDD (SO) in adrenocortical cancer (ACC) patients since other chemotherapeutic regimens have limited effects.PATIENTS AND METHODS:We performed a phase II study with SO therapy in 40 ACC patients (
Eriksson, Barbro,   +8 more
core  

Effect of Opuntia ficus - indica L. Fruit on Blood Glucose Level in Streptozocin Induced Diabetic Rats

open access: yesJournal of Medicinal Plants, 2008
Background: Diabetes mellitus is a prevalent metabolic disorder. Insulin and oral hypoglycemic drugs are the basis of diabetes therapy. Nevertheless they have important side effects and are not always satisfactory in maintaining euglycemia and avoiding ...
S Kianbakht, H Fallah Huseini
doaj  

MORPHOLOGICAL OBSERVATIONS ON PANCREATIC-ISLET BLOOD-VESSELS IN LOW-DOSE STREPTOZOCIN-TREATED MICE [PDF]

open access: yes, 1993
The aim of this study was to observe modifications occurring within the blood vessels of pancreatic islets in low-dose streptozocin (STZ)-treated mice.
CHIEFFI, Gabriella   +2 more
core  

Hypoglycemic effect of Satureja montanum L. hydroethanolic extract on diabetic rats [PDF]

open access: yesJournal of HerbMed Pharmacology, 2016
ntroduction: Diabetes is one of the most prevalent metabolic disorders which is associated withseveral complications in different organs. Nowadays, medicinal herbs are being widely used totreat diseases. This study was conducted to study the hypoglycemic
Mirazi Naser   +2 more
doaj  

Immunomodulation of low dose streptozocin diabetes in mice reveals that insulitis is not obligatory for B cell destruction [PDF]

open access: yes, 1992
Twenty male C57B16/J mice were injected with 50 μl complete Freund's adjuvant (CFA) 1 wk before and 1 wk after induction of diabetes with 45 mg streptozocin (STZ)/kg body weight i.p. over 5 d. CFA administration prevented islet infiltration. Inflammatory
CHIEFFI, Gabriella   +2 more
core  

Pancreatic duct infiltration in the low-dose streptozocin-treated mouse [PDF]

open access: yes, 1994
The pancreatic-duct system was observed during the initial stage of type 1 diabetes in C57BLI6J mice rendered diabetic with low doses of streptozocin.
Linn, T., Papaccio, G., Strate, C.
core  

The streptozocin model of diabetes induces neuropathic pain, anhedonia and impaired burrowing in rats [PDF]

open access: yes, 2015
Many diabetic patients experience chronic neuropathic pain leading to a reduced quality of life which poses a huge economic burden to the health system and society.
Lione, Lisa
core  

Identification and Validation of the Pyroptosis-Related Hub Gene Signature and the Associated Regulation Axis in Diabetic Keratopathy

open access: yesJournal of Diabetes Research
Background. Diabetic keratopathy (DK) poses a significant challenge in diabetes mellitus, yet its molecular pathways and effective treatments remain elusive. The aim of our research was to explore the pyroptosis-related genes in the corneal epithelium of
Yi Cui   +7 more
doaj   +1 more source

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