Results 91 to 100 of about 56,294 (245)

The Effect of Chronic Oral Administration of Withania Somnifera Root on Learning and Memory in Diabetic Rats Using Passive Avoidance Test

پزشکی بالینی ابن سینا, 2006
Introduction & Objective: Diabetes mellitus (especially type I) is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals.
Mehrdad Roghani, Tourandokht Baluchnejadmojarad, Mohsen Khalili, Seyyedeh Fatemeh Mahdavi Salimi   +3 more
doaj  

Nephroprotective and Anti-Diabetic Potential of Beta vulgaris L. Root (Beetroot) Methanolic Extract in a Rat Model of Type 2 Diabetes Mellitus

Medicina
Background and Objectives: Diabetes mellitus is a chronic metabolic disease associated with several complications, including that of kidney disease. Plant-based dietary products have shown promise in mitigating these effects to improve kidney function ...
Laila Naif Al-Harbi, Ghedeir M. Alshammari, Ghalia Shamlan, Manal Abdulaziz Binobead, Sahar Abdulaziz AlSedairy, Doha M. Al-Nouri, Shaista Arzoo, Mohammed Abdo Yahya   +7 more
doaj   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Increased Serum Superoxide Dismutase and Catalase Activities in Streptozotocin-Induced Diabetic Rats

Medical Laboratory Journal, 2014
Background and Objective: One of the diabetes complications is the tissue damage caused by the imbalance of oxidants and antioxidants (oxidative stress).
E Kharazi-Nejad, A Nakhaee, M Taheri
doaj  

In Vitro Astroglial Dysfunction Induced by Neurotoxins: Mimicking Astrocytic Metabolic Alterations of Alzheimer’s Disease

Metabolites
Astrocytes play fundamental roles in the maintenance of brain homeostasis. The dysfunction of these cells is widely associated with brain disorders, which are often characterized by variations in the astrocyte protein markers GFAP and S100B, in addition ...
Jéssica Taday, Fernanda Telles Fróes, Marina Seady, Carlos Alberto Gonçalves, Marina Concli Leite   +4 more
doaj   +1 more source

SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism

Cell Proliferation, EarlyView.
This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang, Juan He, Jing Zheng, Bing Shao, Lixin Shi, Miao Zhang   +5 more
wiley   +1 more source

Effects of decompression on behavioral, electrophysiologic, and histomorphologic recovery in a chronic sciatic nerve compression model of streptozotocin-induced diabetic rats

Journal of Pain Research, 2017
Ping-Hui Wang,1 Cheng-Chang Yang,2 Wei-Ren Su,3 Po-Ting Wu,3 Shun-Chien Cheng,1 I-Ming Jou4 1Department of Orthopedics, Chi-Mei Medical Center, 2Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 3Department of ...
Wang PH, Yang CC, Su WR, Wu PT, Cheng SC, Jou IM   +5 more
doaj  

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

NAA10 and BTRC drive CREBRF degradation in endoplasmic reticulum stress and renal tubular injury

Journal of Diabetes Investigation, EarlyView.
In diabetic kidney disease (DKD), the acetyltransferase NAA10 mediates the acetylation of CREBRF, promoting its recognition and binding by the E3 ubiquitin ligase BTRC, thereby enhancing the ubiquitination level of CREBRF and accelerating its degradation.
Sitian Fang, Jing Ning, Jinjing Huang, Yanxia Chen   +3 more
wiley   +1 more source

Sustainable Intervention: Grape Pomace Flour Ameliorates Fasting Glucose and Mitigates Streptozotocin-Induced Pancreatic Damage in a Type 2 Diabetes Animal Model

Pharmaceuticals
Background/Objectives: Type 2 Diabetes Mellitus (T2DM) is characterized by hyperglycemia, increased risk of cardiovascular diseases, and oxidative imbalances.
Raphaela Cassol Piccoli, William Sanabria Simões, Solange Vega Custódio, Kelen Cristiane Machado Goularte, Karina Pereira Luduvico, Julia Eisenhardt de Mello, Anita Avila de Souza, Ana Carolina Teixeira, Diego Araujo da Costa, Alethéa Gatto Barschak, Bruna Ferrary Deniz, Wellington de Almeida, Paula Pereira, Marisa Nicolai, Roselia Maria Spanevello, Francieli Moro Stefanello, Rejane Giacomelli Tavares, Maria Lídia Palma   +17 more
doaj   +1 more source