Results 111 to 120 of about 188,322 (318)

Antidiabetic effect of Opuntia dillenii seed oil on streptozotocin-induced diabetic rats

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To assess the antidiabetic effect of Opuntia dillenii seed oil on rats with diabetes mellitus. Methods: A rat diabetes model was established by intraperitoneal injection of rats with 50 mg/kg streptozotocin.
Mohamed Bouhrim, Hayat Ouassou, El Hassania Loukili, Mohammed Ramdani, Hassane Mekhfi, Abderrahim Ziyyat, Abdelkhaleq Legssyer, Mohammed Aziz, Mohamed Bnouham   +8 more
doaj   +1 more source

Recent Perspectives on Phytochemical Profile, Pharmacological Activities, and Industrial Applications of Guava (Psidium guajava)

Food Safety and Health, EarlyView.
Psidium guajava leaves contain potent bioactive compounds like quercetin, myricetin, and triterpenoids that show antioxidant, antidiabetic, anti‐inflammatory, and anticancer effects. They act by modulating NF‐κB, PPARγ, and α‐glucosidase and by inducing apoptosis and cell cycle arrest.
Muhammad Waqar, Sehrish Jabbar, Qudrat Ullah, Farhang Hameed Awlqadr, Muhammad Tayyab Arshad, Md. Sakhawot Hossain, Sammra Maqsood, Ali Ikram, Ammar Ahmad Khan, Worawan Panpipat, Manat Chaijan   +10 more
wiley   +1 more source

The effect of Urtica dioica extract on the number of astrocytes in the dentate gyrus of diabetic rats [PDF]

, 2009
Diabetes mellitus is associated with cerebral alterations in both human and animal models of the disease. These alterations include abnormal expression of hypothalamic neuropeptides and hippocampal astrogliosis.
Afshar, M., Golalipour, M.J., Jahanshahi, M.   +2 more
core  

Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans

Journal of Diabetes and Metabolic Disorders, 2013
Streptozotocin (STZ) (2-deoxy-2-({[methyl(nitroso)amino]carbonyl}amino)-β-D-glucopyranose) is a naturally occurring diabetogenic compound, produced by the soil bacterium streptomyces achromogenes, that exhibits broad spectrum of antibacterial properties.
C. Eleazu, K. Eleazu, S. Chukwuma, Udeme Nelson Essien   +3 more
semanticscholar   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

Insights into early pathogenesis of sporadic Alzheimer’s disease: role of oxidative stress and loss of synaptic proteins

Frontiers in Neuroscience
Oxidative stress, induced by impaired insulin signaling in the brain contributes to cognitive loss in sporadic Alzheimer’s disease (sAD). This study evaluated early hippocampal oxidative stress, pre- and post-synaptic proteins in intraperitoneal (IP) and
Mubeen A. Ansari, Muddanna Sakkattu Rao, Aishah Al-Jarallah   +2 more
doaj   +1 more source

Pemberian Ekstrak Etanol Daun Salam untuk Menurunkan Ekspresi TGF-β Podosit Glomerulus Tikus Sprague dawley Diabetes Melitus [PDF]

, 2014
Latar Belakang : Diabetes melitus merupakan kelompok sindrom metabolik yang dapat mengakibatkan peningkatan growth factor pada glomerulus, salah satunya yaitu ekspresi TGF-β di podosit.
rumaolat, wiwi
core  

Effect of Combined Leaf Extracts of Vernonia amygdalina (Bitter Leaf) and Gongronema latifolium (Utazi) on the Pancreatic beta-Cells of Streptozotocin- Induced Diabetic Rats [PDF]

, 2011
The study evaluated the effect of combined extracts of Vernonia amygdalina (VA) and Gongronema latifolium (GL) on the pancreas of streptozotocin (STZ) induced diabetic Wistar rats. Thirty-two (32) albino rats were divided equally into 4 groups.
Akpantah, Amabe, Akpaso, Mfon I, Atangwho, Item J, Ebong, Patrick E, Fischer, Victor A, Igiri, Anozeng O.   +5 more
core   +1 more source

Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic Rats

International Journal of Molecular Sciences, 2014
The use of nanoparticles in medicine is an attractive proposition. In the present study, zinc oxide and silver nanoparticles were evaluated for their antidiabetic activity. Fifty male albino rats with weight 120 ± 20 and age 6 months were used.
A. Alkaladi, Aaser M. Abdelazim, M. Afifi   +2 more
semanticscholar   +1 more source

Berberine alleviates cell pyroptosis in diabetic retinopathy by regulating AKT1, JUN, and STAT3

Ibrain, EarlyView.
Berberine alleviates diabetic retinopathy by reducing pyroptosis through AKT1/JUN/STAT3 regulation, as validated in rat models via network pharmacology, molecular docking, and experimental assays. Abstract Berberine (BBR) exerts an effective protection for diabetic retinopathy (DR), but the underlying key molecular mechanism remains unknown; this study
Na Li, Ji‐Lin Chen, Yi‐Jian Sun, Jia‐Fan Sun, Fatin Athirah Pauzi, Song‐Lin Zhu, Amy Yi Hsan Saik, Alan Han‐Kiat Ong   +7 more
wiley   +1 more source