Results 131 to 140 of about 188,322 (318)

Hepatotoxicity and Langerhans Islets Regenerative Effects of Polar and Neutral Lipids of Nigella sativa L. in Nicotinamide/streptozotocin-Induced Diabetic Rats

Pteridines, 2011
The extracted oil from Nigella sativa seeds is reported to be effective against various diseases and chemicallyinduced hepatotoxicity and nephrotoxicity.
Sobhi Widad, Khettal Bachra, Belmouhoub Messaoud, Atmani Djebbar, Duez Pierre, Benboubetra Mustapha   +5 more
doaj   +1 more source

High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling [PDF]

, 2014
© 2014, Springer-Verlag Berlin Heidelberg. Abstract: ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that play essential roles in human physiology through a coupling mechanism of internal Ca 2+ store to Ca 2+ influx ...
Atkin, Stephen L., Ayoola, James, Berglund, Lisa,, Bhandari, Sunil, Chen, Gui-Lan, Daskoulidou, Nikoleta, Gomez, Maria,, Griffin, Steven, Jiang, Hongni, Kotova, Olga,, Lund University., Lund University., Lund University., Xu, Shang-Zhong, Zeng, Bo   +14 more
core   +1 more source

Immunological and periodontal benefits of prebiotic polydextrose in rats with induced periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Prebiotic therapy is a promising approach for managing periodontitis due to its potential benefits in modulating the microbiome and the immune response. This study aimed to evaluate the effects of the prebiotic (PREB) polydextrose (PDX) on the development of experimental periodontitis (EP) in rats.
Raquel de S. F Nassar, Marcella C. Ribeiro, Ana Carolina P. Hernandes, Laura Z. Gianduzzo, Vanessa de P. S. Pereira, Sérgio L. S. Salvador, Edilson Ervolino, Débora S. F. Sávio, Michel R. Messora, Flávia A. C. Furlaneto   +9 more
wiley   +1 more source

Effect of gestational diabetes on purkinje and granule cells distribution of the rat cerebellum in 21 and 28 days of postnatal life [PDF]

, 2015
Introduction: Diabetes mellitus is associated with nervous system alterations in both human and animal models. This study was done to determine the effect of gestational diabetes on the Purkinje and granular cells in the cerebellum of rat offspring ...
Ghafari, S., Golalipour, M.J., Razi, E.M.   +2 more
core   +1 more source

Tonicity response element binding protein associated with neuronal cell death in the experimental diabetic retinopathy [PDF]

, 2014
AIM: To study the contribution of tonicity response element binding protein (TonEBP) in retinal ganglion cell (RGC) death of diabetic retinopathy (DR). METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/
Choi, Wan-Sung, Chung, Inyoung, Kim, Hwajin, Kim, Seong-Jae, Kwon, H. Moo, Park, Jeongsook, Yoo, Ji-Myong   +6 more
core   +2 more sources

Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin‐induced insulin‐deficient diabetic mice by restoring brown adipose tissue function

Diabetes, obesity and metabolism, 2015
To investigate the effects of LY2405319, an analogue of fibroblast growth factor 21 (FGF21), on glucose homeostasis in streptozotocin (STZ)‐induced insulin‐deficient mice (STZ mice).
Jeongshik Kim, Kwi-Hyun Bae, Yeon-Kyung Choi, Y. Go, M. Choe, Yong Hyun Jeon, Hye Won Lee, Seung-Hoi Koo, J. Perfield, Robert A. Harris, I. Lee, Keun-Gyu Park   +11 more
semanticscholar   +1 more source

Alogliptin Reduces Oxidative Stress in Cardiomyocytes and Ameliorates Diabetic Cardiomyopathy via the AURKB/NLGN2 Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus. This study investigated the effects of alogliptin on DCM and its underlying mechanisms. A DCM model was constructed and treated with alogliptin. Downstream targets of alogliptin were screened using bioinformatics analysis.
Li‐Jing Jiao, Jing Zhou, Jing Wang, Si‐Nan Zhao, Zhan‐Sheng Zhao, Qian Wang, Ya‐Nan Xie, Wei Jiao   +7 more
wiley   +1 more source

Streptozotocin Stimulates the Ion Channel TRPA1 Directly

Journal of Biological Chemistry, 2015
Background: Streptozotocin produces diabetes and diabetic neuropathy in experimental animals. Results: Streptozotocin stimulates TRPA1 through oxidation of cysteine residues, which leads to acute sensory changes in vivo. Conclusion: Cysteine oxidation is
D. Andersson, M. Filipović, C. Gentry, M. Eberhardt, N. Vastani, A. Leffler, P. Reeh, S. Bevan   +7 more
semanticscholar   +1 more source

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li, Xue Wang, Wei Du, Qian Li, Hong‐Ping Cui   +4 more
wiley   +1 more source

Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease [PDF]

, 2019
BACKGROUND: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives.
Antunes, A, Coelho, N, Correia, MJ, Gonçalves-Dias, C, Macedo, MP, Monteiro, E, Morello, J, Soto, K, et al.   +7 more
core   +1 more source