Results 151 to 160 of about 151,903 (303)
Andrology, EarlyView.ABSTRACT Background Diabetes mellitus (DM) induces multifaceted cellular and structural alterations in the male reproductive system, thereby predisposing to infertility. Objectives This study aimed to evaluate the morphological, stereological, biochemical, histopathological, and ultrastructural changes induced by DM in testicular tissue, and to ...
Ayşenur Kaya Mutlu, Süleyman Kaplan
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, 1991 SUMMARY Multiple low doses of streptozotocin arc known to induce immune-mediated insulin deficient diabetes and depression of immune reactivity.
H KOLB, G KANTWERK-FUNKE, V BURKART
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Amylin analogues as a novel perspective in anti‐obesity therapy
British Journal of Pharmacology, EarlyView.Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
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Ventricular arrhythmias following coronary artery occlusion in the streptozotocin diabetic rat
, 1988 The following investigation was designed to assess whether or not streptozotocin diabetes has an influence on the number and severity of ventricular arrhythmias following coronary artery occlusion in the conscious rat. In addition, electrocardiogram and
J. H. McNeill, G. N. Beatch
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Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
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Serum androgen levels after streptozotocin administration in the male rat
, 1988 Serum levels of testosterone and dihydrotestosterone were measured in control and diabetic animals 5, 10 and 15 days after streptozotocin administration.
Centol, I. +6 more
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British Journal of Pharmacology, EarlyView.The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli +6 more
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, 2009 We determined the roles of maximal systolic elastance (E-max ) and theoretical maximum flow (Q(max)) in the regulation of cardiac pumping function in early streptozotocin (STZ)- diabetic rats.
CHANG, KUO-CHU;LO, HUEY-MING;TSENG, YUNG-ZU +1 more
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Evaluating EndoC βH5 pseudoislets as a model for human islet transplantation
Diabetic Medicine, EarlyView.Abstract Aims The EndoC βH5 cell line represents a promising human β‐cell model for preclinical diabetes research. Indeed, EndoC βH5 cells aggregate into islet‐like organoids, secrete insulin in a glucose‐dependent manner, and express a variety of β‐cell functional markers.
Lydia F. Daniels Gatward +11 more
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Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Animal models of prediabetes (Pre‐DM) are essential for studying metabolic disease and testing therapies, yet high‐fat diet (HFD) and HFD‐plus‐streptozotocin (STZ) protocols vary in feeding duration, STZ dose, and diagnostic criteria and rarely account for sex.
Min Xu +7 more
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