Results 141 to 150 of about 56,294 (245)

Therapeutic Effect of Zingerone on Reproductive Damage in Diabetic Male Rats: Potential Role of Sirt1/Nrf2/HO‐1 and Bax/Bcl‐2 Signaling Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
Diabetes mellitus causes significant damage to the male reproductive system. Sirt1/Nrf2/HO‐1 signaling pathway acts as a line of defense against ROS in reproductive organs. In STZ‐induced diabetic rats, the proapoptotic Bax protein expression was found to be elevated, whereas the antiapoptotic Bcl‐2 protein expression was reduced.
Edanur Güler Ekmen, Mehmet Çay, İbrahim Halil Güngör, Ali Osman Çeribaşı   +3 more
wiley   +1 more source

Spinal Implant–Associated Infection in Type 2 and Type 1 Diabetes: Phenotype‐Specific Inflammatory Features and Therapeutic Response to Semaglutide

JOR SPINE, Volume 9, Issue 2, June 2026.
ABSTRACT Background Diabetes mellitus (DM) is a major risk factor for postoperative infection and wound complications in spine surgery, yet distinctions between Type 2 (T2DM) and Type 1 (T1DM) pathophysiology are rarely addressed. This study compares infectious burden, wound healing, and immune response among a murine model of spinal implant‐associated
Thomas E. Olson, Trevor S. Lloyd, Christopher D. Hamad, Rene F. Chun, Joshua Wiener, Autreen Golzar, Joshua Mehany, Soroush Shahamatdar, Andrew Kittredge, Lauren Pearce, Kevin P. Francis, Farres Obeidin, Langston T. Holly, Michael R. Yeaman, John S. Adams, Nicholas M. Bernthal, William L. Sheppard   +16 more
wiley   +1 more source

Retraction of "Anti-diabetic Activity of Brucine in Streptozotocin-Induced Rats: <i>In Silico</i>, <i>In Vitro</i>, and <i>In Vivo</i> Studies". [PDF]

ACS Omega
Khan NU, Qazi NG, Khan AU, Ali F, Hassan SSU, Bungau S.   +5 more
europepmc   +1 more source

Statement of Retraction: Interleukin-17A attenuates photoreceptor cell apoptosis in streptozotocin-induced diabetic mouse model. [PDF]

Bioengineered
europepmc   +1 more source

Alogliptin Reduces Oxidative Stress in Cardiomyocytes and Ameliorates Diabetic Cardiomyopathy via the AURKB/NLGN2 Signaling

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.
ABSTRACT Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus. This study investigated the effects of alogliptin on DCM and its underlying mechanisms. A DCM model was constructed and treated with alogliptin. Downstream targets of alogliptin were screened using bioinformatics analysis.
Li‐Jing Jiao, Jing Zhou, Jing Wang, Si‐Nan Zhao, Zhan‐Sheng Zhao, Qian Wang, Ya‐Nan Xie, Wei Jiao   +7 more
wiley   +1 more source

Statement of Retraction: Nesfatin-1 protects against diabetic cardiomyopathy in the streptozotocin-induced diabetic mouse model via the p38-MAPK pathway. [PDF]

Bioengineered
europepmc   +1 more source

Betanin Modulates the Leptin-Adiponectin Axis and Improves Glycemic Control in a High-Fat Diet and Streptozotocin-Induced Rat Model of Type 2 Diabetes. [PDF]

Cureus
Agrawal S, Kumar R, Jain A, Singh S, Singh S, Dixit R.   +5 more
europepmc   +1 more source

Biogenic Silver Nanoparticles in Diabetes: In Vivo Mechanisms, Therapeutic Potential, and Future Perspectives: A Review

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
Biogenic silver nanoparticles exhibit antidiabetic potential by improving glycemic control, enhancing insulin sensitivity, and preserving pancreatic β‐cell function. They act through antioxidant and anti‐inflammatory mechanisms, modulating ROS, NF‐κB, and PI3K/Akt pathways, while providing multi‐organ protection, highlighting their promise as ...
Nourhane A. Darwich, Rana El Hajj, Mahmoud I. Khalil   +2 more
wiley   +1 more source

Hippo-YAP Signaling Drives Epigenetic Vulnerability in the Diabetic Heart via the miR-22-3p-SIRT1 Axis: Linking Metabolic Stress to Chromatin Control. [PDF]

Diabetes
Jankauskas SS, Varzideh F, Santulli G.
europepmc   +1 more source

Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres, Helena Á. Ferrero, Pablo Castañera, Jesús Llano‐Verdeja, Sergio Fernández‐Martínez, Amanda Herrero‐González, Farzaneh Javadimarand, Roberto López, Jesús F. Aparicio, Andrew M. Edwards, Volker Behrends, Luis M. Mateos, Álvaro Mourenza, Michal Letek   +13 more
wiley   +1 more source