Results 141 to 150 of about 188,322 (318)
Phytotherapy Research, EarlyView.ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet +10 more
wiley +1 more source
Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid [PDF]
, 2013 Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8-oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and glutamic acid were ...
Ali, Saqib +9 more
core +1 more source
Naunyn-Schmiedeberg's Archives of Pharmacology, 2015 Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset.
G. Ali +5 more
semanticscholar +1 more source
Amylin analogues as a novel perspective in anti‐obesity therapy
British Journal of Pharmacology, EarlyView.Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley +1 more source
Iranian South Medical Journal, 2020 Background: Diabetes is one of the most prevalent diseases in the world with its side effects, for instance in reproductive system. Probiotics are beneficial microorganisms that have preventive and therapeutic effects. The present study aimed to evaluate
Samira Abasi, Zahra Keshtmand
doaj
Goettingen Minipigs (GMP): Comparison of Two Different Models for Inducing Diabetes
Diabetology & Metabolic Syndrome, 2012 Purpose Preclinical experiments on large animals are indispensable for evaluating the effectiveness of diabetes therapies. Miniature swine are well suited for such studies due to their physiological and pathophysiological responses.
Strauss Armin +7 more
doaj +1 more source
International Journal of Medical Sciences, 2015 Diabetes mellitus (DM) is caused by either destruction of pancreatic β-cells (type 1 DM) or unresponsiveness to insulin (type 2 DM). Conventional therapies for diabetes mellitus have been developed but still needs improvement. Many diabetic patients have
Ki-Jong Rhee +5 more
semanticscholar +1 more source
Brazilian Journal of Medical and Biological Research, 1997 Autonomic neuropathy is a frequent complication of diabetes associated with higher morbidity and mortality in symptomatic patients, possibly because it affects autonomic regulation of the sinus node, reducing heart rate (HR) variability which predisposes
B.D. Schaan +9 more
doaj +1 more source
SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism
Cell Proliferation, EarlyView.This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang +5 more
wiley +1 more source
LIN28A blocks the EndMT process of high glucose‐induced HRMECs by stabilizing SIRT6 mRNA
Journal of Diabetes Investigation, EarlyView.LIN28A promotes mRNA stability of SIRT6 to activate the AMPK signaling, thereby inhibiting the EndMT process induced by HG in HRMECs. ABSTRACT Background Diabetic retinopathy (DR) is a microvascular condition resulting from microangiopathy, causing gradual retinal damage and potential blindness.
Xueying Wang +5 more
wiley +1 more source