Results 161 to 170 of about 151,903 (303)

Effects of GLP‐1 agonists on the gut microbiota in type 2 diabetes mellitus: a systematic review

The FEBS Journal, EarlyView.
This systematic review evaluated 17 studies (12 preclinical and five clinical) on GLP‐1 receptor agonists in type 2 diabetes, demonstrating effects on the gut microbiota and metabolic improvement. The studies showed an increase in Bacteroidetes, Lactobacillus, and Akkermansia, and a reduction in Firmicutes.
Ranicleide Santos Dantas, Lucas Vinícius Souza Santos, André Gustavo Carvalho de Oliveira, Marina dos Santos Barreto, Deise Maria Rego Rodrigues Silva, Pedro Henrique Macedo Moura, Eloia Emanuelly Dias Silva, Ronaldy Santana Santos, Lucas Alves da Mota Santana, Rajiv Gandhi Gopalsamy, Adriana Gibara Guimarães, Lysandro Pinto Borges   +11 more
wiley   +1 more source

USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6‐induced ferroptosis and angiogenesis inhibition

Journal of Diabetes Investigation, EarlyView.
High glucose upregulates USP30 in HUVECs, which deubiquitinates and stabilizes TRAF6. Stabilized TRAF6 suppresses GPX4 and SLC7A11, increases ROS/MDA/lipid peroxidation, and activates ferroptosis and apoptosis, leading to impaired angiogenesis and delayed wound healing.
Jingjing Yuan, Shuang Sui, Zhenghua Yang, Kaiwen Zhang, Qiang Hu   +4 more
wiley   +1 more source

Optimalisasi Pemberian Streptozotocin Beberapa Dosis terhadap Peningkatan Kadar Gula Darah Tikus Sprague dawley [PDF]

, 2017
Streptozotocin merupakan derivat sintetik dari nitrosourea glukopiranosa hasil fermentasi Streptomyces achromogenes. Salah satu peranannya adalah menghambat sekresi insulin dan menyebabkan terjadinya insulin-dependent diabetes mellitus (IDDM).
Harijanto, Elbert Aldrin, Dewajanti, Anna Maria   +1 more
core  

The miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell injury in diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
Suppression of miR‐145‐5p alleviates DN‐associated renal tissue damage by inhibiting NRF2/SLC7A11‐mediated ferroptosis of RTECs. ABSTRACT Purpose This study aimed to investigate the molecular mechanism by which the miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell (RTEC) injury in diabetic nephropathy (DN ...
Ganlin Wu, Yu Fang, Meirong Xu, Zuopeng Lu, Yu Cao, Yana Gao   +5 more
wiley   +1 more source

Treatment Effects of Onion on Spermatogenesis in Streptozotocin-induced Diabetic Rat

Journal of Medicinal Plants, 2009
Background: Onion has significant blood sugar lowering action. Objective: Antioxidants have essential effect on spermatogenesis and sperm parameters. Streptozotocin can dioceses oxidative stress and changes in antioxidant capacity are considered to play ...
B Gholamhosini, A Khaki, HR Ahmadi-Ashtiani, Sh Rezazadeh, H Rastegar, F Fathiazad, M Ghanbari   +6 more
doaj  

AMELIORATION OF STREPTOZOTOCIN-INDUCED HYPERGLYCEMIA AND DYSLIPIDEMIA THROUGH ALOE DEBRANA [PDF]

, 2015
Objective: To study the antiglycemic and antidyslipidemic effects of an ethanolic extract of Aloe debrana leaf gel extract in streptozotocin-induced diabetic rats.Methods: A. debrana leaves were collected from Enemore district; Gurage area Ethiopia.
Suleyman, Abdilkadir, Gnanasekaran, Natesan, Daniel, Seifu   +2 more
core  

Liraglutide reprograms vascular smooth muscle cell metabolism to suppress extracellular matrix remodeling in diabetic atherosclerosis

Journal of Diabetes Investigation, EarlyView.
Liraglutide reverses hyperglycemia‐induced metabolic reprogramming in vascular smooth muscle cells, restoring mitochondrial function and AMPK/PGC‐1α signaling while suppressing mTOR activation and HIF‐1α accumulation. These changes attenuate extracellular matrix remodeling, reduce atherosclerotic plaque burden, and improve plaque stability in diabetic ...
Kun Zhu, Hanxiu Liu, Ni He, Haoyang Wang, Jing Liu, Qinhu Zhang, Zhongwei Liu   +6 more
wiley   +1 more source

Protective Effects of Urtica Dioica Extract on the Damage of Rat Small Intestinal Mucosa Caused by Diabetes

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2012
BACKGROUND AND OBJECTIVE: Urtica is a dioecious plant, which has been introduced in Iranian traditional medicine as anti-diabetes. Since, the metabolic disorder caused by diabetes causes secondary pathophysiologic changes in multiple organs of the body ...
T Rezaei Aref, B Minaii Zangii, M Latifpour   +2 more
doaj  

Role of glucagon in metabolic diseases

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Currently, diabetes is defined as “a chronic hyperglycemic state resulting from the absolute or relative insufficiency of insulin action,” emphasizing its characterization as an insulin‐related disease. However, glucagon dysregulation should also play a critical role in the pathophysiology of type 2 diabetes.
Tadahiro Kitamura, Yoko Tabei, Masaki Kobayashi   +2 more
wiley   +1 more source

Effect of grape seed extract on β -catenin gene expression and hyperglycemia in rats induced by streptozotocin [PDF]

Eurasian Journal of Veterinary Sciences
Aim: Type 2 Diabetes Mellitus is a metabolic disorder characterized by high blood sugar in case of insulin resistance and/or insulin deficiency or insufficiency.
Elif Gulbahce-Mutlu, Emine Arslan, Hilal Arikoglu   +2 more
doaj