Results 101 to 110 of about 151,903 (303)

Anti-hyperglycemic activity of selenium nanoparticles in streptozotocin-induced diabetic rats

International Journal of Nanomedicine, 2015
The study was designed to investigate the anti-hyperglycemic activity of selenium nanoparticles (SeNPs) in streptozotocin-induced diabetic rats. Fifty-five mg/kg of streptozotocin was injected in rats to induce diabetes. Animals either treated with SeNPs
S. Al-Quraishy, M. Dkhil, A. A. Abdel Moneim   +2 more
semanticscholar   +1 more source

Chrysin attenuates diabetes‐induced retinal injury by inhibiting microglial GBP3/NLRP3/GSDMD‐mediated pyroptosis

Animal Models and Experimental Medicine, EarlyView.
We investigated the therapeutic potential and mechanism of chrysin in experimental diabetic retinal disease. Using a streptozotocin (STZ)‐induced diabetic mouse model and high‐glucose‐stimulated BV2 microglia, we revealed chrysin‐responsive pyroptosis‐associated signatures and identified GBP3 as a regulated node.
Qun Liu, Song‐min Wang, Xuan Chen, Yi‐rao You, Chen‐jiao Guo, Chang‐qin Xie, Lu‐lu Wang, Qi Liu, Lan Zhang, Jun‐tao Yang   +9 more
wiley   +1 more source

Evaluation of in vivo antidiabetic, antidyslipidemic and in vitro antioxidant activities of hydromethanolic root extract of Datura stramonium L. (Solanaceae)

Journal of Experimental Pharmacology, 2019
Yaschilal Muche Belayneh,1 Zewdu Birhanu,2 Eshetie Melese Birru,2 Gedefaw Getenet1 1Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia; 2Department of Pharmacology, School of Pharmacy, College of Medicine ...
Belayneh YM, Birhanu Z, Birru EM, Getenet G   +3 more
doaj  

Hippocampal acetylcholinesterase activation induced by streptozotocin in mice is protected by an organotellurium compound without evidence of toxicity [PDF]

Anais da Academia Brasileira de Ciências
The cognitive deficit, which is like Alzheimer’s disease and is associated with oxidative damage, may be induced by exposure to streptozotocin.
NILCE C. PEIXOTO, JAMILE S. BERNARDI, CLÁUDIA S. OLIVEIRA, MARIANA SUELEN C. SANTOS, SARA L. MARION, RAFAEL S. SILVA, RAQUEL M. ROSA, OSCAR E.D RODRIGUES, MARIA ESTER PEREIRA   +8 more
doaj   +1 more source

Antidiabetic Activity of Zinc Oxide and Silver Nanoparticles on Streptozotocin-Induced Diabetic Rats

International Journal of Molecular Sciences, 2014
The use of nanoparticles in medicine is an attractive proposition. In the present study, zinc oxide and silver nanoparticles were evaluated for their antidiabetic activity. Fifty male albino rats with weight 120 ± 20 and age 6 months were used.
A. Alkaladi, A. Abdelazim, M. Afifi
semanticscholar   +1 more source

Hepatotoxicity and Langerhans Islets Regenerative Effects of Polar and Neutral Lipids of Nigella sativa L. in Nicotinamide/streptozotocin-Induced Diabetic Rats

Pteridines, 2011
The extracted oil from Nigella sativa seeds is reported to be effective against various diseases and chemicallyinduced hepatotoxicity and nephrotoxicity.
Sobhi Widad, Khettal Bachra, Belmouhoub Messaoud, Atmani Djebbar, Duez Pierre, Benboubetra Mustapha   +5 more
doaj   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

The Needle‐Free Frontier: Redefining the Limits of Transdermal Insulin Delivery

Exploration, EarlyView.
Wei and colleagues reported a pH‐responsive, charge‐switchable polyzwitterionic polymer carrier that achieves non‐invasive transdermal insulin delivery without external energy input. The approach leverages adaptive compatibility with the cutaneous microenvironment to shuttle functional macromolecules across intact skin and achieve definitive systemic ...
Junge Chen, Yuxuan Liu, Bozhang Xia, Julien Milon Essola, Xing‐Jie Liang   +4 more
wiley   +1 more source

Portulaca oleracea L. alleviates liver injury in streptozotocin-induced diabetic mice

, 2017
Guoyin Zheng,1,* Fengfeng Mo,2,* Chen Ling,3,* Hao Peng,1 Wei Gu,1 Min Li,2 Zhe Chen1 1Department of Traditional Chinese Medicine, Changhai Hospital, 2Department of Military Hygiene, Second Military Medical University, 3Department of Biology, School of ...
Peng H, Ling C, Chen Z, Gu W, Zheng G, Mo F, Li M   +6 more
core  

Diabetes is associated with impairment of uterine contractility and high Caesarean section rate [PDF]

, 2011
Aims/hypothesis The prevalence of births worldwide complicated by diabetes mellitus is increasing. In the UK, for example,
S. Al-Qahtani, S. Wray, Al-Qahtani, S., Dawood, F., A. Heath, Burdyga, T., T. Burdyga, Quenby, Siobhan, F. Dawood, S. Quenby, Wray, S., Heath, Andrew C., R. Floyd, Floyd, R.   +13 more
core   +1 more source