Results 101 to 110 of about 188,322 (318)
An emerging protagonist: Sodium Glucose Co-transporters (SGLTs) as a burgeoning target for the treatment of diabetes mellitus [PDF]
, 2012 Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. The kidney emerges out as
Danish Ahmed +3 more
core +2 more sources
Food Chemistry International, EarlyView.Acha–chia–soycake biscuits improved glucose tolerance, lipid profile, insulin levels, and pancreatic integrity in HFD–STZ diabetic rats. ACSB1 and ACSB13 outperformed acarbose, showing potent antihyperglycemic, hypolipidemic, and pancreatic‐protective effects.
Oluwafunmilayo Christianah Ogunnowo +5 more
wiley +1 more source
Journal of Pharmacy and Bioallied Sciences, 2014 Aim: To examine the preventive effect of Aloe vera gel ethanolic extract using diabetic foot ulcer (DFUs) protocol in Wistar rats. Materials and Methods: Male Wistar rats were divided into untreated control (Group I), untreated DFUs (Group II), DFUs ...
Mohan Daburkar +4 more
doaj +1 more source
Modeling type 2 diabetes in rats using high fat diet and streptozotocin
Journal of Diabetes Investigation, 2014 The pathology of type 2 diabetes is complex, with multiple stages culminating in a functional β‐cell mass that is insufficient to meet the body's needs.
Søs Skovsø
semanticscholar +1 more source
A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation
Food Chemistry International, EarlyView.Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee +4 more
wiley +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2020 Sushil Dubey, Chandrabhan Yadav, Anand Bajpeyee, Mohan P Singh Centre of Biotechnology, University of Allahabad, Prayagraj, Uttar Pradesh, IndiaCorrespondence: Mohan P SinghCoordinator, Centre of Biotechnology Institute of Interdisciplinary Studies (IIDS)
Dubey S, Yadav C, Bajpeyee A, Singh MP
doaj
Mìžnarodnij Endokrinologìčnij Žurnal, 2017 Background. The purpose of our research was a comparative analysis of specificity and severity of kidney dysfunction in the early period of alloxan- and streptozotocin-induced diabetes mellitus. Materials and methods. The article presents data concerning
T.M. Boychuk +3 more
doaj +1 more source
Mode of Action of Streptozotocin [PDF]
Journal of Bacteriology, 1971 Streptozotocin induces rapid degradation of deoxyribonucleic acid (DNA) in actively dividing or resting Bacillus subtilis cells. Difference spectroscopy showed that the antibiotic interacts specifically with cytosine containing mononucleotides in vitro. This interference occurs only within the very narrow
openaire +2 more sources
Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content
Food Safety and Health, EarlyView.By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao +8 more
wiley +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2020 Zemene Demelash Kifle,1 Yaschilal Muche Belayneh2 1Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Wollo ...
Kifle ZD, Belayneh YM
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