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Microvascular Homeostasis Is Compromised in Pancreatic Islets in a Mouse Model of β-Cell Loss and Low-Grade Inflammation. [PDF]

Diabetes
Gonçalves LM, Shirvaikar I, Sideris K, Pereira E, Slak Rupnik M, Almaça J.   +5 more
europepmc   +1 more source

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Streptozotocin as a tool for induction of rat models of diabetes: a practical guide

EXCLI Journal : Experimental and Clinical Sciences, 2023
Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type 1 and type 2 diabetes. Despite ~60 years of using STZ in animal diabetes research, some prevailing views about STZ preparation and use are not supported by ...
A. Ghasemi, S. Jeddi
semanticscholar   +1 more source

Streptozotocin‐Induced Diabetic Models in Mice and Rats

Current Protocols in Pharmacology, 2015
Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM).
B. Furman
exaly   +2 more sources

TREATMENT OF INSULINOMA WITH STREPTOZOTOCIN

Lancet, The, 1969
Y, Arnould, H A, Ooms, P A, Bastenie
exaly   +3 more sources

POTENTIAL CARCINOGENIC EFFECT OF STREPTOZOTOCIN

Lancet, The, 1969
T M, Sibay, J A, Hayes
exaly   +3 more sources

KETOSIS IN STREPTOZOTOCIN DIABETES

Lancet, The, 1969
Lionel Opie, Keith Mansford
exaly   +2 more sources

Genotoxicity of Streptozotocin

Mutation Research/Reviews in Mutation Research, 2002
Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals through its toxic effects on pancreatic beta cells.
Alejandro D, Bolzán, Martha S, Bianchi
openaire   +2 more sources