Results 61 to 70 of about 151,903 (303)

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions of Verbascum Sinaiticum Benth (Scrophulariaceae) Leaves in Mice

Journal of Experimental Pharmacology, 2023
Beyene Dereje,1 Aschalew Nardos,2 Jemal Abdela,3 Lidet Terefe,2 Melese Arega,4 Terfo Mikre Yilma,5 Tilahun Tesfaye6 1Department of Pharmacology, School of Medicine, College of Medicine and Health Science, Dire Dawa University, Dire Dawa, Ethiopia ...
Dereje B, Nardos A, Abdela J, Terefe L, Arega M, Yilma TM, Tesfaye T   +6 more
doaj  

Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer’s Disease: in Search of a Relevant Mechanism

Molecular Neurobiology, 2015
Streptozotocin (STZ), a glucosamine-nitrosourea compound derived from soil bacteria and originally developed as an anticancer agent, in 1963 has been found to induce diabetes in experimental animals.
P. Grieb
semanticscholar   +1 more source

Efeito da diabetes mellitus tipo 1 na função mitocondrial [PDF]

, 2011
Mestrado em Bioquímica-Métodos BiomulecularesDespite type 1 diabetes mellitus being more rare, it has an autoimmune origin and appears early in life, greatly affecting its quality.
Carvalho, Tiago Filipe Cruz
core  

Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species‐Scavenging, Oxygen‐Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing

Advanced Science, EarlyView.
CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu, Xiaodong Luo, Jingxian Wu, Chaoyang Huang, Zhuoying Yang, Yixiang HePeng, Bosong Zhou, Xiang Li, Ruiyuan Liu, Xu Wu   +9 more
wiley   +1 more source

Streptozotocin-induced rodent models of diabetes: Protocol comparisons

, 2014
Type 1 and type 2 diabetes mellitus (DM) are characterized by hyperglycemia, due to lost or damaged insulin-producing β-cells within the pancreatic islets of Langerhans.
Cintra, Luciano T.A. [UNESP], Gomes-Filho, Joäo E. [UNESP], Dezan-Júnior, Eloi [UNESP], Samuel, Renata O. [UNESP]   +3 more
core   +1 more source

Streptozotocin-induced diabetes mellitus in pigs

, 1993
We induced, as a precondition for a pancreas transplant, insulin-dependent diabetes mellitus in 67 Yorkshire Landrace pigs by administering streptozotocin.
Nakhleh, R, Grüssner, A, Diem, P, Sutherland, D, Grüssner, R, Tomadze, G   +5 more
core   +1 more source

Soft Hypoxia‐Adaptive Bioelectronics Integrating PEDOT:PSS/Polydopamine/Enzyme Biocomposites for Closed‐Loop Therapeutics of Chronic Wounds

Advanced Science, EarlyView.
Hypoxia‐adaptive bioelectronics based on poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/polydopamine (PDA)/enzyme biocomposites couple O2‐centric biosensing with embedded O2 therapy to address oxygen‐deficient chronic wounds. Local O2 provision restores enzyme‐based metabolite sensing, while catalase‐mediated oxygen generation and
Songrui Liu, Bowen Yang, Cao Qi, Zhijie Zhou, Haochen Zou, Anjum Qureshi, Xiao Zhao, Ting Li, Li Gao, Ye Tao, Gang Song, Pingqiang Cai, Zheng Li, Zhiyuan Liu, Dianpeng Qi, Ting Wang, Lianhui Wang   +16 more
wiley   +1 more source

Antidiabetic and antioxidant activity of ethyl acetate extract fraction of Moringa oleifera leaves in streptozotocin-induced diabetes rats via inhibition of inflammatory mediators

, 2018
Objective: To evaluate the antioxidant and antidiabetic mechanism(s) of ethyl acetate extract fraction of Moringa oleifera (M. oleifera) leaves on streptozotocin-induced diabetes in male Sprague-Dawley rats.
Ghazi A. Bamagous, Saeed Al Ghamdi, Ibrahim Abdel Aziz Ibrahim, A. Mahfoz, M. Afify, M. Alsugoor, A. Shammah, P. Arulselvan, T. Rengarajan   +8 more
semanticscholar   +1 more source

Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2015
Chronic hyperglycemia and the corresponding glucotoxicity are the main pathogenic mechanisms of diabetes and its complications. Streptozotocin (STZ)-induced diabetic animal models are useful platforms for the understanding of β cell glucotoxicity in ...
Jinzi Wu, Liang-Jun Yan
semanticscholar   +1 more source