Results 41 to 50 of about 151,903 (303)

Effect of Phenolic and Alkaloid Extract of Senna Occidentalis Leaf on the Oxidative Status of the Heart in High Fat-Diet Streptozotocin-Induced Type 2 Diabetic Wistar Rats

World Journal of Traditional Chinese Medicine
Objective: This research examined the effects of extracts (alkaloid and phenolic) from the leaves of Senna occidentalis on the oxidative status of heart in Wistar rats fed high-fat diets and induced with streptozotocin. Type 2 diabetes was established in
Emmanuel Saviour Saheed, Mutiat A. Abdulkareem, Fehintoluwa Celestina Adeleke   +2 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats

Oxidative Medicine and Cellular Longevity, 2018
Diabetic cardiomyopathy is a diabetic complication due to oxidative stress injuries. This study examined the protecting influence of thymoquinone (TQ) on diabetes-caused cardiac complications.
M. S. Atta, A. El‑Far, F. Farrag, Mohamed M. Abdel-Daim, S. A. Al Jaouni, S. Mousa   +5 more
semanticscholar   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Quercetin mitigates hepatic injury by inhibiting TGF-β/p-Smad3 signaling pathway activation and enhancing AMPK activity in type 2 diabetic rats

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the effects of quercetin on inflammatory signaling pathways and hepatic oxidative injury using a streptozotocin-induced liver injury model.
Hanaa F. B. Gaber, Mohamed K. Mahfouz, Fatma SM Moawed, Esraa SA Ahmed, Omayma AR Abo-Zaid   +4 more
doaj   +1 more source

SIRT1 Activation by Equisetum arvense L. (Horsetail) Modulates Insulin Sensitivity in Streptozotocin Induced Diabetic Rats

Molecules, 2020
BACKGROUND: Equisetum arvense L., commonly known as field horsetail is a perennial fern of which extracts are rich sources of phenolic compounds, flavonoids, and phenolic acids.
Csaba Hegedűs, Mariana Muresan, Andrea Badale, Mariann Bombicz, Balázs Varga, Anna Szilágyi, Dávid Sinka, Ildikó Bácskay, Mihaela Popoviciu, Ioan Magyar, Mária Magdolna Szarvas, Erzsébet Szőllősi, József Németh, Zoltán Szilvássy, Annamaria Pallag, Rita Kiss   +15 more
doaj   +1 more source

The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats

Evidence-Based Complementary and Alternative Medicine, 2017
This study was conducted to compare the ameliorative effect of Nigella sativa and propolis methanol extract on streptozotocin-induced diabetic male rats and treating diabetic nephropathy.
H. E. El Rabey, M. Al-Seeni, Amal S Bakhashwain   +2 more
semanticscholar   +1 more source

Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

Advanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin, Yu Zhang, Xinyu Qu, Jiayi Liu, Zhongyi Sun, Haibo Liu, Ziyan Chen, Jing Ru, Jingwen Han, Bingqiang Lu, Yan Lu, Yan Wang, Xinyu Zhao, Feng Chen   +13 more
wiley   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Effect of Gynura procumbens leaf extract with biological nanoparticles on streptozotocin-induced hyperglycemia in a rat model

Journal of Advanced Biotechnology and Experimental Therapeutics
Herbal medicines, a popular choice for treatments, are effective against diabetes when used with nanoparticles. Thus, this study investigates the effects of Gynura procumbens ethanolic extract with chitosan nanoparticles on streptozotocin-induced ...
Shahadat Alam Badsha, Rakibul Islam, Mst. Misrat Masuma Parvez, Md. Bazlar Rashid, Md. Mahmudul Hasan, Vishakha Kulkarni, Sumon Sarkar   +6 more
doaj   +1 more source