Results 31 to 40 of about 188,322 (318)

Pancreatic β-cell protective effect of novel GABA derivatives in rats with type 2 diabetes

Research Results in Pharmacology, 2023
Introduction: Gamma-aminobutyric acid (GABA) and GABAergic compounds emerged as potential therapeutic agents for diabetes mellitus and its complications.
Ivan N. Tyurenkov, Dmitry A. Bakulin, Yulia I. Velikorodnaya, Alexander V. Borisov, Elizaveta E. Abrosimova, Alexey V. Smirnov, Grigoriy L. Snigur, Svyatoslav S. Surin, Daria A. Kavalerova, Olga S. Vasilyeva   +9 more
doaj   +1 more source

Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats [PDF]

, 2017
The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells.
Berretta, Erica, De Stefano, Maria Egle, Florenzano, Fulvio, Gelfo, Francesca, Manni, Luigi, Nisticã², Robert, Petrosini, Laura, Piccinin, Sonia, Protto, Virginia, Soligo, Marzia   +9 more
core   +2 more sources

Resistance of CA1 pyramidal cells to STZ-induced diabetes in young rats [PDF]

, 2009
The pyramidal cell density of CA1 hippocampal subfield following STZ-induced diabetes in young rats were studied. 12 male albino 6-week Wistar rats were allocated equally in groups of normal and diabetic. Hyperglycemia induced by Streptozotocin (80 mg/kg)
Behnampour, N., Fazeli, S.A., Ghafari, S., Gharravi, A.M., Golalipour, M.J., Jahanshahi, M.   +5 more
core   +1 more source

The preventive and treatment effect of Urtica dioica on astrocyte density in the CA1 and CA3 subfields of hippocampus in STZ induced diabetic rats [PDF]

, 2013
Several animal model studies have shown that Diabetes mellitus can affect on the activity of hippocampus astrocytes, but these studies reported controversial findings.
Afshar, M., Ghafari, S., Golalipour, M.J., Jahanshahi, M.   +3 more
core   +1 more source

β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer’s Disease

Biomolecules, 2019
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by a cascade of changes in cognitive, behavioral, and social activities. Several areas of the brain are involved in the regulation of memory.
Sundas Hira, U. Saleem, Fareeha Anwar, M. Sohail, Zohaib Raza, B. Ahmad   +5 more
semanticscholar   +1 more source

Stability of a type 2 diabetes rat model induced by high-fat diet feeding with low-dose streptozotocin injection

Journal of Zhejiang University SCIENCE B, 2018
The present study aims at determining the stability of a popular type 2 diabetes rat model induced by a high-fat diet combined with a low-dose streptozotocin injection.
Xiaoxuan Guo, Yong Wang, Kai Wang, B. Ji, F. Zhou   +4 more
semanticscholar   +1 more source

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor. [PDF]

, 2016
Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity.
Bakirtzi, K, Cheng, M, Fisseha, E, Fleshner, P, Gallo, RL, Hing, TC, Ho, S, Hoang-Ngoc Tran, D, Hoang-Yen Tran, D, Karagiannides, I, Koon, HW, Law, I, Lee, EC, Lee, JE, Li, Z, Mattai, SA, McGovern, DPB, Ortiz, C, Robbins, L, Sallam, T, Shieh, C, Shih, DQ, Sideri, A, Su, B, Targan, SR, Vu, M   +25 more
core   +1 more source

Improving the Reliability and Utility of Streptozotocin-Induced Rat Diabetic Model

Journal of Diabetes Research, 2018
The Streptozotocin- (STZ-) induced diabetic model is widely used; however, unexplained acute toxicity has given the model an unreliable reputation. To improve the reliability and utility of this model, we characterize the age dependence of STZ toxicity ...
Yanlin Wang-Fischer, T. Garyantes
semanticscholar   +1 more source

Acción de la estreptozotocina en un modelo experimental de inducción neonatal de la diabetes

Biomédica: revista del Instituto Nacional de Salud, 2016
Introducción. El estudio de la diabetes mediante modelos experimentales es fundamental para entender los mecanismos fisiopatológicos de la enfermedad. Objetivos.
Leticia Bequer, Tahiry Gómez, José Luis Molina, Daniel Artiles, Rosa Bermúdez, Sonia Clapés   +5 more
doaj   +1 more source

Quercetin improved spatial memory dysfunctions in rat model of intracerebroventricular streptozotocin-induced sporadic Alzheimer’sdisease [PDF]

, 2015
Background: Alzheimer’s disease (AD) is one of the most common neurodegenerative syndromes characterized by a progressive decline in the spatial memory. There are convincing evidences on the neuroprotective effects of flavonoids against AD.
Ashrafpour, M., Parsaei, S., Sepehri, H.
core   +1 more source