Streptozotocin‐Induced Diabetic Models in Mice and Rats
Current Protocols in Pharmacology, 2015 Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM).
Brian L. Furman
semanticscholar +1 more source
Journal of Pharmacopuncture, 2023 Objectives: The study's goal was to find out whether Chrysanthemum rubellum extract has anti-diabetic properties by concentrating on α-glucosidase and the PTP-1B signaling pathway. C. rubellum flowers were used for extraction using Methanol/water (80/20)
Bichitrananda Tripathy +2 more
doaj +1 more source
Pancreatic β-cell protective effect of novel GABA derivatives in rats with type 2 diabetes
Research Results in Pharmacology, 2023 Introduction: Gamma-aminobutyric acid (GABA) and GABAergic compounds emerged as potential therapeutic agents for diabetes mellitus and its complications.
Ivan N. Tyurenkov +9 more
doaj +1 more source
Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice [PDF]
, 2014 The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2.
Rabbani, Naila +11 more
core +1 more source
Effect Of Spray-dried Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats. [PDF]
, 2006 The objective of this study was to evaluate the effect of commercially prepared spray-dried ethanolic extract ol Andrographis paniculafa (AP) on streptozotocin (STZ)-induced diabetic female rats.
Amrah, S. S. +6 more
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Biomolecules, 2019 Alzheimer’s disease (AD) is a neurodegenerative disease characterized by a cascade of changes in cognitive, behavioral, and social activities. Several areas of the brain are involved in the regulation of memory.
Sundas Hira +5 more
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Acción de la estreptozotocina en un modelo experimental de inducción neonatal de la diabetes
Biomédica: revista del Instituto Nacional de Salud, 2016 Introducción. El estudio de la diabetes mediante modelos experimentales es fundamental para entender los mecanismos fisiopatológicos de la enfermedad. Objetivos.
Leticia Bequer +5 more
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An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin
Nature, 2019 Small molecules containing the N-nitroso group, such as the bacterial natural product streptozotocin, are prominent carcinogens1,2 and important cancer chemotherapeutics3,4.
Tai L. Ng +4 more
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Improving the Reliability and Utility of Streptozotocin-Induced Rat Diabetic Model
Journal of Diabetes Research, 2018 The Streptozotocin- (STZ-) induced diabetic model is widely used; however, unexplained acute toxicity has given the model an unreliable reputation. To improve the reliability and utility of this model, we characterize the age dependence of STZ toxicity ...
Yanlin Wang-Fischer, T. Garyantes
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Inhibitory Potential of Six Brown Algae from the Persian Gulf on α-Glucosidase and In Vivo Antidiabetic Effect of Sirophysalis Trinodis [PDF]
Iranian Journal of Medical Sciences, 2022 Background: Brown algae have gained worldwide attention due to their significant biological activities, such as antidiabetic properties. In the present study, the antidiabetic properties of six brown algae from the Persian Gulf were investigated.Methods:
Nioofar Moheimanian +3 more
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