Results 11 to 20 of about 56,294 (245)

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics
AbstractBackgroundDiabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
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Effect of Hydroxytyrosol on Prdx6 Expression in Diabetic Rat Liver

Düzce Tıp Fakültesi Dergisi, 2023
Aim: Oxidative stress caused by hyperglycemia, which is the most important complication of diabetes mellitus, causes liver damage. Hydroxytyrosol is a polyphenolic compound abundant in olive oil that protects the liver against oxidative damage ...
Eda Nur Almalı, Kayihan Karacor, Hakan Soylu   +2 more
doaj   +1 more source

The Effect of Streptozotocin and Streptozotocin-Induced Diabetes on the Kidney

Kidney and Blood Pressure Research, 1984
The study of diabetic nephropathy in experimental animals generally relies on the chemical induction of the diabetic state. Streptozotocin is commonly employed to that end; however, streptozotocin has an inherent nephrotoxic potential. We studied the effects of both streptozotocin, and diabetes on the kidneys of rats given streptozotocin 60 mg/kg ...
A P, Evan, S A, Mong, V H, Gattone, B A, Connors, G R, Aronoff, F C, Luft   +5 more
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Enzymatic virgin coconut oil effect on urea and creatinine levels of hypercholesterolemia-diabetics induced Wistar male rats [PDF]

Pharmaciana
Coconut (Cocos nucifera L.) is an Indonesian commodity that has high economic value tall. Virgin Coconut Oil (VCO) is one of the processed coconut products whose selling value is very high, because the composition of VCO consists of medium-chain fatty ...
Niluh Puspita Dewi, Syafika Alaydrus, Nadila, Magfirah, Joni Tandi, Viani Anggi, Nani Astria Polontalo   +6 more
doaj   +1 more source

Antidiabetic Effect of Standardized Chrysanthemum rubellum Hydroethanolic Extract by Targeting α-Glucosidase and the PTP-1B Signaling Pathway for Alleviating Diabetes in Experimental Model

Journal of Pharmacopuncture, 2023
Objectives: The study's goal was to find out whether Chrysanthemum rubellum extract has anti-diabetic properties by concentrating on α-glucosidase and the PTP-1B signaling pathway. C. rubellum flowers were used for extraction using Methanol/water (80/20)
Bichitrananda Tripathy, Nityananda Sahoo, Sudhir Kumar Sahoo   +2 more
doaj   +1 more source

Pancreatic β-cell protective effect of novel GABA derivatives in rats with type 2 diabetes

Research Results in Pharmacology, 2023
Introduction: Gamma-aminobutyric acid (GABA) and GABAergic compounds emerged as potential therapeutic agents for diabetes mellitus and its complications.
Ivan N. Tyurenkov, Dmitry A. Bakulin, Yulia I. Velikorodnaya, Alexander V. Borisov, Elizaveta E. Abrosimova, Alexey V. Smirnov, Grigoriy L. Snigur, Svyatoslav S. Surin, Daria A. Kavalerova, Olga S. Vasilyeva   +9 more
doaj   +1 more source

Acción de la estreptozotocina en un modelo experimental de inducción neonatal de la diabetes

Biomédica: revista del Instituto Nacional de Salud, 2016
Introducción. El estudio de la diabetes mediante modelos experimentales es fundamental para entender los mecanismos fisiopatológicos de la enfermedad. Objetivos.
Leticia Bequer, Tahiry Gómez, José Luis Molina, Daniel Artiles, Rosa Bermúdez, Sonia Clapés   +5 more
doaj   +1 more source

Inhibitory Potential of Six Brown Algae from the Persian Gulf on α-Glucosidase and In Vivo Antidiabetic Effect of Sirophysalis Trinodis [PDF]

Iranian Journal of Medical Sciences, 2022
Background: Brown algae have gained worldwide attention due to their significant biological activities, such as antidiabetic properties. In the present study, the antidiabetic properties of six brown algae from the Persian Gulf were investigated.Methods:
Nioofar Moheimanian, Hossein Mirkhani, Jelveh Sohrabipour, Amir Reza Jassbi   +3 more
doaj   +1 more source

Induction of diabetes by Streptozotocin in rats [PDF]

Indian Journal of Clinical Biochemistry, 2007
The objective of this study is to induce experimental diabetes mellitus by Streptozotocin in normal adult Wistar rats via comparison of changes in body weight, consumption of food and water, volume of urine and levels of glucose, insulin and C-peptide in serum, between normal and diabetic rats.
A, Akbarzadeh, D, Norouzian, M R, Mehrabi, Sh, Jamshidi, A, Farhangi, A Allah, Verdi, S M A, Mofidian, B Lame, Rad   +7 more
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Mode of Action of Streptozotocin [PDF]

Journal of Bacteriology, 1971
Streptozotocin induces rapid degradation of deoxyribonucleic acid (DNA) in actively dividing or resting Bacillus subtilis cells. Difference spectroscopy showed that the antibiotic interacts specifically with cytosine containing mononucleotides in vitro. This interference occurs only within the very narrow
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