Neuroprotective effect of normal and modified mesenchymal stem cell-derived exosomes by mitigating Alzheimer's-related oxidative and inflammatory damage via Nrf2/HO-1 in SH-SY5Y cells. [PDF]
IbrainExosome therapy shows promise in Alzheimer's disease. This study compared normal and modified exosomes from AD brain extract‐treated MSCs in STZ‐induced SH‐SY5Y cells. Exosomes improved neuronal viability, reduced oxidative stress and inflammation, and activated Nrf2/HO‐1 signaling.
Dhapola R +4 more
europepmc +2 more sources
LIPID METABOLISM IN DIABETIC RATS AS AFFECTED BY CANOLA AND MUSTARD SEED SPROUTS [PDF]
Arab Universities Journal of Agricultural Sciences, 2018 Canola (Brassica juncea L.) and mustard (Sinapis alba L.) seed sprout effects on diabetic rats have no available information and to clarify their effects, both sprouts were investigated in streptozotocin (STZ) induced diabetic and normal rats. Rats were
Hanaa Amer +4 more
doaj +1 more source
Life, 2021 The objective of the study was to compare the effects of experimentally induced type 1 or type 2 diabetes (T1D or T2D) on the functional, structural and biochemical properties of mouse peripheral nerves. Eight-week-old C57BL/6 mice were randomly assigned
Julia Jaroslawska +7 more
doaj +1 more source
Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats
Scientific Reports, 2020 The effects of quercetin liposomes (Q-PEGL) on streptozotocin (STZ)-induced diabetic nephropathy (DN) was investigated in rats. Male Sprague Dawley rats were used to establish a STZ induced DN model.
Lixia Tang +6 more
semanticscholar +1 more source
Journal of Applied Sciences and Environmental Management, 2018 Diabetes epidemics pose a serious health care problems and a huge burden on the economy of both developed and developing nations. Precise prognosis and the discovery of cost effective drugs for its management would serve as catalyst to economic recovery.
M Osibemhe, O.M. Bello, N Lawal
doaj +1 more source
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.
Physiological Research, 2001 Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action in B cells of the pancreas has been intensively investigated and now is quite well understood.
T. Szkudelski
semanticscholar +1 more source
Effect of Hydroxytyrosol on Prdx6 Expression in Diabetic Rat Liver
Düzce Tıp Fakültesi Dergisi, 2023 Aim: Oxidative stress caused by hyperglycemia, which is the most important complication of diabetes mellitus, causes liver damage. Hydroxytyrosol is a polyphenolic compound abundant in olive oil that protects the liver against oxidative damage ...
Eda Nur Almalı +2 more
doaj +1 more source
Streptozotocin-Induced Astrocyte Mitochondrial Dysfunction Is Ameliorated by FTO Inhibitor MO-I-500
, 2021 The pathogenesis of Alzheimer’s disease (AD), the most prevalent form of dementia, remains unclear. Over the past few years, evidence has accumulated indicating that perturbed cerebral bioenergetics and neuroinflammation may compromise cognitive ...
Mark J. Olsen (11403323) +9 more
core +1 more source
Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid [PDF]
, 2013 Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8-oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and glutamic acid were ...
Shah, Syed Qaisar +9 more
core +4 more sources
Enzymatic virgin coconut oil effect on urea and creatinine levels of hypercholesterolemia-diabetics induced Wistar male rats [PDF]
PharmacianaCoconut (Cocos nucifera L.) is an Indonesian commodity that has high economic value tall. Virgin Coconut Oil (VCO) is one of the processed coconut products whose selling value is very high, because the composition of VCO consists of medium-chain fatty ...
Niluh Puspita Dewi +6 more
doaj +1 more source