Results 41 to 50 of about 4,685,827 (307)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Does Cardiorespiratory Fitness Buffer Stress Reactivity and Stress Recovery in Police Officers? A Real-Life Study

Frontiers in Psychiatry, 2020
High levels of cardiorespiratory fitness have the potential to buffer against physical and mental health impairments, which can result from exposure to occupational stress.
René Schilling, Christian Herrmann, Sebastian Ludyga, Flora Colledge, Serge Brand, Serge Brand, Serge Brand, Serge Brand, Serge Brand, Uwe Pühse, Markus Gerber   +10 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Evaluating cognitive bias in clinical ethics supports: a scoping review

BMC Medical Ethics
Background A variety of cognitive biases are known to compromise ethical deliberation and decision-making processes. However, little is known about their role in clinical ethics supports (CES).
Louise Giaume, Antoine Lamblin, Nathalie Pinol, Frédérique Gignoux-Froment, Marion Trousselard   +4 more
doaj   +1 more source

Exploring the relationship between occupational stress, physical activity and sedentary behavior using the Job-Demand-Control Model

Frontiers in Public Health
ObjectivesTo study the relationship between the occupational stress model, specifically the Job Demand-Control Model of Karasek, physical activity level and sedentary behavior.MethodThis is a cross-sectional, observational, descriptive study.
Maëlys Clinchamps, Céline Bibily, Jean-Baptiste Bouillon-Minois, Ukadike C. Ugbolue, Marion Trousselard, Bruno Pereira, Frédéric Dutheil   +6 more
doaj   +1 more source

The multitasking framework: the effects of increasing workload on acute psychobiological stress reactivity [PDF]

, 2014
A variety of techniques exist for eliciting acute psychological stress in the laboratory; however, they vary in terms of their ease of use, reliability to elicit consistent responses and the extent to which they represent the stressors encountered in ...
Wetherell, Mark, Carter, Kirsty, Kirsty Carter, Mark A. Wetherell   +3 more
core   +1 more source

Stress-induced tradeoffs in a free-living lizard across a variable landscape: consequences for individuals and populations. [PDF]

PLoS ONE, 2012
Current life history theory suggests that the allocation of energetic resources between competing physiological needs should be dictated by an individual's longevity and pace of life. One key physiological pathway likely to contribute to the partitioning
Leilani D Lucas, Susannah S French
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An investigation into the use of infrared thermography as a tool to assess the physiological stress response in the horse [PDF]

, 2011
The experiments reported in this thesis investigated the use of temperature measurement using infrared thermography (IRT) as an objective, non-invasive method to identify the physiological stress response in the horse.
Yarnell, K
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source