Results 51 to 60 of about 985,739 (265)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Estresse crônico melhora a função miocárdica sem alterar a atividade do canal-L para Ca+2 em ratos Chronic stress improves the myocardial function without altering L-type Ca+2 channel activity in rats

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: O estresse crônico está associado à remodelação cardíaca; entretanto, os mecanismos permanecem a ser descobertos. OBJETIVO: A proposta deste estudo foi testar a hipótese de que o estresse crônico promove disfunção cardíaca associada a ...
Thiago Bruder-Nascimento, Dijon Henrique Salome Campos, André Soares Leopoldo, Ana Paula Lima-Leopoldo, Katashi Okoshi, Sandra Cordellini, Antônio Carlos Cicogna   +6 more
doaj  

Embodied stress: The physiological resonance of psychosocial stress

Psychoneuroendocrinology, 2019
Psychosocial stress is a ubiquitous phenomenon in our society. While acute stress responses are necessary and adaptive, excessive activation of neurobiological stress systems can predispose an individual to far-reaching adverse health outcomes. Living in a complex social environment, experiencing stress is not limited to challenges humans face ...
Veronika Engert, Roman Linz, Joshua A. Grant   +2 more
openaire   +4 more sources

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Role of stress in progression of Migraine

International Journal of Endorsing Health Science Research, 2014
The mental and physiological stresses can be an important trigger of migraines & headaches. These strains act to enhance the progression of migraine that could be psychological, physiological stress, Environmental stress or Chemical stress.
Shamoon Noushad, Sadaf Ahmed, Huma Khalid, Rida Nasir, Ikram Tunio, Shaikh Tahir   +5 more
doaj   +1 more source

Neurological Soft Signs and Post-Traumatic Stress Disorder: A Biomarker of Severity?

Frontiers in Psychiatry, 2020
BackgroundThe psychophysiological changes for individual suffering from chronic post-traumatic stress disorder (PTSD) raise to the questions of how facilitate recovery and return to work.
Célia Belrose, Célia Belrose, Célia Belrose, Anais Duffaud, Anais Duffaud, Elsa Rakotoarison, Catherine Faget, Philippe Raynaud, Philippe Raynaud, Frédéric Dutheil, Frédéric Dutheil, Léa Boyer, Jean-Baptiste Billaud, Marion Trousselard, Marion Trousselard, Marion Trousselard   +15 more
doaj   +1 more source