Results 61 to 70 of about 4,685,827 (307)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Examination of the bovine leukocyte environment using immunogenetic biomarkers to assess immunocompetence following exposure to weaning stress [PDF]

, 2011
peer-reviewedBackground: The molecular mechanisms by which stress induces the development of pathologies remains unclear, although it is recognised that one of the major factors affecting health as a consequence of stress is the involvement of the ...
McGee, Mark, Waters, Sinead M., O'Loughlin Aran, O'Loughlin, Aran, Aran O'Loughlin, McGee Mark, Mark McGee, Earley Bernadette, Bernadette Earley, Doyle, Sean, Doyle Sean, Sinéad M Waters, Sean Doyle, Earley, Bernadette, Waters Sinéad M   +14 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Evaluation of physiological and morphological basis for drought resistance in maize and sorghum [PDF]

, 2004
Includes bibliographical references (leaves 145-171).Drought stress is often the most limiting factor to maize and sorghum production in the semi-arid areas.
Takele, Abuhay
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Physiological effects of heart rate variability biofeedback during laboratory induced congnitive stress [PDF]

, 2012
Includes bibliographical references.Heart rate variability (HRV) biofeedback is effective in reducing stress as well as managing chronic disease. It facilitates easy manipulation of HRV, and, therefore, potentially provides a valuable intervention for ...
Prinsloo, Gabriell Elizabeth
core   +1 more source

The impact of sugar-sweetened beverage intake on rat cardiac function

Heliyon, 2019
Aims: Although there is evidence linking sugar-sweetened beverage (SSB) intake with the development of cardio-metabolic diseases, the underlying mechanisms remain unclear.
Natasha Driescher, Danzil E. Joseph, Veronique R. Human, Edward Ojuka, Martin Cour, Nkanyiso Hadebe, Dirk Bester, Jeanine L. Marnewick, Sandrine Lecour, Amanda Lochner, M. Faadiel Essop   +10 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Physiological stress markers, mental health and objective physical function

, 2020
Objective: The observed poorer physical function in persons with mental disorders could partly be due to dysregulation in physiological stress systems.
Lever-van Milligen, Bianca A, Lamers, Femke, Smit, Johannes H, Penninx, Brenda W J H   +3 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source