Results 71 to 80 of about 985,739 (265)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Plant Responses and Tolerance to Salt Stress: Physiological and Molecular Interventions 2.0. [PDF]
Int J Mol Sci, 2023 Hasanuzzaman M, Fujita M.
europepmc +1 more source
EFFECT OF WORKPLACE STRESS ON JOB PERFORMANCE
Economic Review, 2015 The study examines the relationship between workplace stress and job performance. A survey method was employed to gather self-administered questionnaires from executive and non-executive employees of a leading private investment bank in Peninsular ...
Azman Ismail +4 more
doaj +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Dynamics in physiological acute stress response trajectories: uncovering latent variability
BMC PsychiatryBackground Acute stressors trigger an immediate physiological response, involving multiple intricating pathways. These adaptive physiological responses include, among other processes, an increase in heart rate (HR) and a decrease in heart rate ...
Shaked Rosenblum +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Plant Responses and Tolerance to Salt Stress: Physiological and Molecular Interventions. [PDF]
Int J Mol Sci, 2022 Hasanuzzaman M, Fujita M.
europepmc +1 more source
Drought as a Form of Abiotic Stress and Physiological Markers of Drought Stress [PDF]
Journal of Stress Physiology & Biochemistry, 2018 Drought is one of the most common forms of abiotic stress and has direct impact on the viability and productivity of plants. From the point of view of physical chemistry, drought is characterized by a decrease of the water potential of the environment ...
J.S. Shumilina +3 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
IEEE AccessStress is a complex factor that simultaneously triggers psychological and physiological changes in humans. However, research on the relationship between stress’s psychological and physiological aspects has been limited.
Jinhak Lee +11 more
doaj +1 more source