Results 91 to 100 of about 4,685,827 (307)

Job-related stress and burnout [PDF]

open access: yes, 2002
Occupational stress is a topic of substantial interest to organizational researchers and managers, as well as society at large. Stress arising from work conditions can be pervasive and significant in its impact on individuals, their families and ...
Cooper, Cary L.   +1 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Characterization of Mental Stress Using Multivariate R-Vine Copula Approach with Physiological Signals

open access: yes
Occupational stress is a well-studied topic, and recent advances in wearable technologies have enabled a way to analyse continuous signals that respond to indicators of stress such as heart rate (HR), electrodermal activity (EDA), skin temperature (TEMP),
Deo, Ravinesh C.   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The physiological and behavioural responses of sheep exposed to heat load within intensive sheep industries [PDF]

open access: yes, 2006
The live export and feedlotting industries are the major intensive sheep industries in Australia. During live shipment, sheep are exposed to prolonged periods of high heat and humidity, with little relief for several days, while environmental conditions ...
Stockman, Catherine Ann
core  

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Gender Variations of Physiological and Psychological Stress among Police Officers [PDF]

open access: yes
This paper analyses the effect of gender on reported and perceived levels of stress through examination of both the physical and psychological indicators.
Martin Gächter   +2 more
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

EFFECT OF WORKPLACE STRESS ON JOB PERFORMANCE

open access: yesEconomic Review, 2015
The study examines the relationship between workplace stress and job performance. A survey method was employed to gather self-administered questionnaires from executive and non-executive employees of a leading private investment bank in Peninsular ...
Azman Ismail   +4 more
doaj   +2 more sources

Patterns of physiological stress response and family climate of stress in children attending Head Start [PDF]

open access: yes, 2015
The repeated activation of physiological stress systems in response to the chronic stress associated with poverty in early childhood signals environmental instability, leading to changes in patterns of physiological response that appear to prepare ...
NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

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