Results 101 to 110 of about 2,002,532 (306)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
EFFECT OF WORKPLACE STRESS ON JOB PERFORMANCE
Economic Review, 2015 The study examines the relationship between workplace stress and job performance. A survey method was employed to gather self-administered questionnaires from executive and non-executive employees of a leading private investment bank in Peninsular ...
Azman Ismail +4 more
doaj +2 more sources
Evaluating Respiratory Sinus Arrhythmia as a Mediator of Relations between Minority Stress and Depressive Symptoms Among Sexual Minorities [PDF]
, 2020 Compared with heterosexuals, those with sexual minority identities (e.g., lesbian, gay, bisexual) are at significantly greater risk of psychopathology, including depression—the most common mental health disorder in the general population. A large body of
Mustafa, Jazmyn
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Music in the relief of stress and distress in cancer patients [PDF]
Revista Brasileira de EnfermagemObjectives: to evaluate the effects of music on the physiological stress and distress of cancer patients being treated in a hospital. Methods: quasi-experimental study carried out with cancer patients hospitalized in the nursing wards of a public ...
Mariana Scheidegger dos Santos +4 more
doaj +4 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Dynamics in physiological acute stress response trajectories: uncovering latent variability
BMC PsychiatryBackground Acute stressors trigger an immediate physiological response, involving multiple intricating pathways. These adaptive physiological responses include, among other processes, an increase in heart rate (HR) and a decrease in heart rate ...
Shaked Rosenblum +2 more
doaj +1 more source
Plant Responses and Tolerance to Salt Stress: Physiological and Molecular Interventions 2.0. [PDF]
Int J Mol Sci, 2023 Hasanuzzaman M, Fujita M.
europepmc +1 more source
Winter wheat: A model for the simulation of growth and yield in winter wheat [PDF]
The basic ideas and constructs for a general physical/physiological process level winter wheat simulation model are documented. It is a materials balance model which calculates daily increments of photosynthate production and respiratory losses in the ...
Baker, D. N. +4 more
core +1 more source