Results 41 to 50 of about 434,967 (262)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

An Analytical Method for Determining the Stress–Strain State of a Subgrade with Combined Reinforcement

Infrastructures
This article presents the fundamentals of an analytical method for determining the stress–strain state of a railway subgrade reinforced with geosynthetic material.
Ahmad Alkhdour, Oleksii Tiutkin, Szabolcs Fischer, Dmytro Kurhan   +3 more
doaj   +1 more source

Bone Stress-Strain State Evaluation Using CT Based FEM

Frontiers in Mechanical Engineering, 2021
Nowadays, the use of a digital prototype in numerical modeling is one of the main approaches to calculating the elements of an inhomogeneous structure under the influence of external forces. The article considers a finite element analysis method based on
Oleg V. Gerasimov, Nikita V. Kharin, Artur O. Fedyanin, Pavel V. Bolshakov, Maxim E. Baltin, Evgeny O. Statsenko, Filip O. Fadeev, Rustem R. Islamov, Tatyana V. Baltina, Oskar A. Sachenkov   +9 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Characterization of Stress State of Corrugated Steel Web Girders Based on Mann-Kendall Criterion

Zhongwai Gonglu
To reasonably characterize the stress state of corrugated steel web girders and determine the failure load, the stress state evolution pattern of corrugated steel web girders was investigated in this paper based on the structural stress state theory ...
DOU Fei, CHEN Feng
doaj   +1 more source

Stress-strain state of concrete element with damage

Bulletin of Prydniprovs’ka State Academy of Civil Engineering and Architecture, 2020
Problem statement. At present, it is relevant to determine the technical condition of structures and their strengthening as needed. Damage of structures affects the process of determining the physical and mechanical characteristics of concrete structures.  Purpose.
Kolokhov, V. V., Sopilniak, M. A., Mospan, V. І.   +2 more
openaire   +3 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Stress-strain state of bending reinforced beams with cracks

Инженерно-строительный журнал, 2020
The work is dealing with studying the stress-strain state of bending pre-stressed concrete beams with cracks. The problems of determining preliminary stresses in a reinforced concrete element, determining the moment of crack formation, and determining ...
Omirkhan Khabidolda, Syrlybek Zholmagambetov, Irina Kurokhtina, Zhmagul Nuguzhinov, Nikolai Vatin, Zhetpisbai Bakirov   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source