Results 41 to 50 of about 457,599 (266)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Investigation of the Behaviour of Cohesive Powder in the Biaxial Tester

KONA Powder and Particle Journal, 2014
The results from experiments with cohesive limestone powder in a Biaxial Tester are presented. The biaxial tester allows a plane homogeneous deformation and measurement of the complete stress-strain states.
Hermann Josef Feise, Jörg Schwedes
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Construction and application of the limit strain surface for evaluating the plasticity of porous bodies

Проблеми трибології
Traditional failure criteria for solid materials are not applicable to powder materials due to the presence of porosity, which acts as a sink for dislocations, alters defect accumulation kinetics, and slows structural degradation.
R. Sivak, L. Polishchuk, V. Shenfeld, A. Ormanbekova, N. Zhumakhan   +4 more
doaj   +1 more source

Comparison of the stress and strain intensity factors for the corner area of the structure boundary

MATEC Web of Conferences, 2018
The stress-strain state of structures in areas with corner cut-outs and cuts of boundaries features the occurrence of areas of stress concentration and requires assessment of strength and reliability of facilities, which is a relevant task in engineering
Frishter Lyudmila
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Some Approaches to Quantitative Classification of Plastic Deformation Processes Based on the Parameters of Their Stress–Strain State Determined by Simulation Modeling

Metals
The article discusses the methods for classifying processes for testing and processing metals by plastic deformation, based on the characteristics of their stress–strain state.
Valentin Kamburov, Rayna Dimitrova
doaj   +1 more source

Deformability parameters for forming the stress-strain state models of rock massif [PDF]

Mining and Metallurgy Engineering Bor, 2013
This paper describes the principle of development the structural models of rocks, based on which the geomechanical model rock massif is developed, to which the applied numerical methods of stress analysis can be applied in solving the practical problems ...
Popović Ratomir, Ljubojev Milenko, Đurđevac-Ignjatović Lidija   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Strain-Stress State of Wood During Drying Process

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2013
The paper proposes theoretical and experimental methods for investigation of strain-stress state of wood and lumber saw-timbers in the process of heated-air drying.
V. A. Sychevsky
doaj